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RESEARCH TOPIC :
PROJECTS :
FUNDING :
FORMER MEMBERS :
AMENDOLA Julien, BRECHET Aline, CHAHINIAN Henri, DE SAN FELICIANO Marina , DEBREUX Kevin, DESPLANTES Richard, DRIHEM Chiraz, EL FAR Oussama , ERARD-GARCIA Madeleine, FLORES Alessandra, GOUGOT Julie, LEVEQUE Christian , LEVY Annie , MAULET Yves , MOUTOT Nicole , RAMIREZ FRANCO José Jorge, SAMARI Nada, SEAGAR Michael, VAN RENTERGHEM Catherine, YOUSSOUF Fahamoe .
PUBLICATIONS :
- 2023 - Azzaz F, Chahinian H, Yahi N, Fantini J, Di Scala C.
AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer's Disease Therapy.
Int J Mol Sci, 24 : 1760 - 2023 - Azzaz F, Hilaire D, Fantini J.
Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors.
Chem Biol Interact, 373 : 110384 - 2022 - Di Scala C, Amstrong N, Chahinian H, Chabrière E, Fantini J, Yahi N.
AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery
Int J Mol Sci, 23 : 13383 - 2022 - Azzaz F, Yahi N, Di Scala C, Chahinian H, Fantini J.
Ganglioside binding domains in proteins: Physiological and pathological mechanisms
Advances in Protein Chemistry and Structural Biology, 128 : 289-324 - 2022 - Azzaz F, Fantini J.
The epigenetic dimension of protein structure
Biomolecular Concepts, 13 : 55-60 - 2022 - Ramirez-Franco JJ, Debreux K, Extrémet J, Maulet Y, Belghazi M, Villard C, Sangiardi M, Youssouf F, El Far L, Lévêque C, Debarnot C, Marchot P, , Debanne D, Russier M, Seagar M, Irani S, El Far O.
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Brain, doi: 10.1093/brain/awac218 - 2022 - Extrémet J, El Far O, Ankri N, Irani SR, Debanne D, Russier M.
An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel
Cells, 11 : 2713 - 2022 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci G, Youssouf F, Popooff MR, Seagar M, Lévêque C, Fantini J, El Far O.
Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
Cell Mol Life Sci, 79 : 496 - 2022 - Azzaz F, Hilaire D, Fantini J.
Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft
Biomolecule, 12 : 1821 - 2021 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci Géraldine, Youssouf F, Popoff Michel Robert, Seagar M, Lévêque C, Fantini J, El Far O.
The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex
BioRxiv - 2021 - Yahi N, Di Scala C, Chahinian H, Fantini J.
Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease
Glycoconjugate Journal - 2021 - Fantini J, Yahi N, Azzaz F, Chahinian H.
Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks
Journal of Infection, 83 : 197-206 - 2021 - Fantini J, Chahinian H, Yahi N.
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19
Biochemical and Biophysical Research Communication, 538 : 132-136 - 2020 - Ramberger M, Berretta A,Tan JMM, Sun B, Michael S, Yeo T, Theorell J, Bashford-Rogers R, Paneva S, O'Dowd V, Dedi N,, Topia S, Griffin R, Ramirez-Franco JJ, El Far O, Baulac S, Leite M, Sen A, Jeans A, McMillan D, Marshall D, Antony D, Lightwood D, Waters P, Irani SR.
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Brain, 143 : 1731-1745 - 2020 - Fantini J, Chahinian H, Yahi N.
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19
Biochemical and Biophysical Research Communications, doi: 10.1016/j.bbrc.2020.10.015. - 2020 - Fantini J, Chahinian H, Yahi N.
Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of Aβ oligomers?
Protein Science, 29 : 1748-1759 - 2020 - Fantini J, Chahinian H, Yahi N.
Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal
International Journal Antimicrobial Agents, 56 : 106020 - 2019 - Flores A, Ramirez-Franco JJ, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf F, Sangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque C, , El Far O.
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1908051116 - 2019 - Rama S, Boumedine N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne D, El Far O.
Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification
Molecular Neurobiology, 56 : 3591-3602 - 2018 - Debanne D, El Far O.
Pre- and post-synaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis
Brain, 141 : 3092-3095 - 2018 - Coralie Di Scala, Fantini J, Yahi N, Francisco J. Barrantes, Chahinian H.
Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter
Biomolecules, 8 - 2018 - Huang Y, Huang S, Di Scala C, Wang Q, Wandall HH, Fantini J, Zhang YQ.
The glycosphingolipid MacCer promotes synaptic bouton2 formation in Drosophila by interacting with Wnt
eLife, 7 : e38183 - 2017 - Connan C, Voillequin M, Chavez CV, Mazuet C1,, Lévêque C, Vitry S, Vandewalle A, Popoff MR.
Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells.
Cellular Microbiology, 19 : e12738 - 2017 - Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine N, Rodriguez L, Zbili M, Usseglio F, Formisano-Treziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne D, , El Far O.
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
Proceedings of the National Academy of Sciences USA, 114 : 7719-7724 - 2017 - Desplantes R, Lévêque C, Muller B, Loterzio M, Ferracci G, Popoff M, Seagar M, Mamoun R, El Far O.
Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor
Scientific Reports, 7 : 1032 - 2015 - Hammond C, El Far O, Seagar M.
Neurotransmitter release
Cellular and molecular neurophysiology - 2015 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Seagar M, El Far O.
A chip-based assay for botulinum neurotoxin A activity in pharmaceutical preparations.
Appl Microbiol Biotechnol. , 99 : 4355-4360 - 2015 - Amendola J, Boumedine N, Sangiardi M, El Far O.
Optimization of neuronal cultures from rat superior cervical ganglia for dual patch recording
Scientific Reports, 5 : 14455 - 2015 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff MR, Blanchard MP, Seagar M, El Far O.
An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E
Scientific Reports, 5 : 17953 - 2015 - El Far O, Seagar M.
The synaptic vesicle V-ATPase: a regulatory link between loading and fusion?
Presynaptic terminals - 2014 - Mlayah-Bellalouna S, Dufour M, Mabrouk S, Mejdoub, H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.
AaTX1, from Androctonus australis scorpion venom: Purification, synthesis and characterization in dopaminergic neurons
Toxicon, 92 : 14-23 - 2014 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff M, Seagar M, El Far O.
Direct biosensor detection of botulinum neurotoxin endopeptidase activity in sera from patients with type A botulism
Biosensors and Bioelectronics, 57 : 207-212 - 2013 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Blanchard MP, Seagar M, El Far O.
A substrate sensor chip to assay the enzymatic activity of Botulinum neurotoxin A.
Biosensors & Bioelectronics, 49 : 276-281 - 2012 - Belzeaux R, Bergon A, Jeanjean V, Loriod B, , Formisano-Treziny C, Verrier L, Loundou A, Baumstarck-Barrau K, Boyer L, Gall V, , Gabert J, Nguyen C, Azorin JM, Naudin J, Ibrahim EC.
Responder and nonresponder patients exhibit different peripheral transcriptional signatures during major depressive episodes
Translational Psychiatry, 2 : e185 - 2012 - Slezak M, Grosche A, Niemiec A,Tanimoto N, Pannicke T, Münch TA , Crocker B, Isope P, Härtig W, Beck SC, Huber G, Ferracci G, Perraut M, Rebert M, Miehe M, Demais V, Lévêque C, Metzger D, Szklarczyk K, Przewlocki R, Seeliger MW, Sage-Ciocca D, Hirrlinger J, Reichenbach A, Reibel S, Prrieger FW.
Relevance of exocytotic glutamate release from retinal glia.
Neuron, 74 : 504-516 - 2011 - El Far O, Seagar M.
SNARE, V-ATPase and neurotransmission
Med Sci (Paris), 27 : 28-31 - 2011 - El Far O, Seagar M.
A role for V-ATPase subunits in synaptic vesicle fusion?
Journal of Neurochemistry, 117 : 603-612 - 2011 - Ferracci G, Marconi S, Mazuet C, Jover E, Blanchard MP, Seagar M, Popoff M, Lévêque C.
A label-free biosensor assay for botulinum neurotoxin B in food and human serum.
Anal Biochem, 410 : 281-288 - 2010 - ElBassiouni S, Amendola J, Durand J, Heckman C J.
Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant SOD1 motoneurons
J Neurosci, 30 : 5544-5558 - 2010 - Karatekin E, Di Giovanni J, Iborra C, Coleman J, O'Shaughnessy B, Seagar M, Rothman JE.
A fast, single-vesicle fusion assay mimics physiological SNARE requirements.
Proc Natl Acad Sci USA, 107 : 3517-3521 - 2010 - Di Giovanni J, Iborra C, Maulet Y, Lévêque C, El Far O, Seagar M.
Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin
J Biol Chem, 285 : 23665-23675 - 2010 - Di Giovanni J, Boudkkazi S, Mochida S, Bialowas A, Samari N, Lévêque C, Youssouf F, Brechet A, Iborra C, Maulet Y, Moutot N, Debanne D, Seagar M, El Far O.
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release.
Neuron, 67 : 268-279 - 2008 - Marconi S, Ferracci G, Berthomieu M, Kozaki S, Miquelis R, Boucraut J, Seagar M, Lévêque C.
A protein chip membrane-capture assay for botulinum neurotoxin activity.
Toxicol Appl Pharmacol, 233 : 439-446 - 2008 - Moutot N, De Haro L, Seagar M.
Distinct evolution of calcium channel antibody types in Lambert-Eaton myasthenic syndrome.
J Neuroimmunol, 197 : 47-53 - 2008 - Marqueze B, Moutot N, Sakkou-Norton M, Lévêque C, Ji Y, Cornet V, Hsiao WL, Seagar M.
Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.
Traffic, 9 : 1088-1100 - 2007 - Bories C, Amendola J, Lamotte d'Incamps B, Durand J.
Early electrophysiological abnormalities in lumbar motoneurons in a transgenic mouse model of amyotrophic lateral sclerosis
Eur J Neurosci, 25 : 451-459 - 2006 - Lacoste C, Barthaux V, Iborra C, Seagar M, Erard-Garcia M.
MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans.
Dev Biol, 294 : 181-191 - 2006 - Moutot N, Mansuelle P, Alcaraz G, Dos Santos RG, Cordeiro MN, De Lima ME, Seagar M, Van Renterghem C.
Phoneutria nigriventer toxin 1: a novel, state-dependent inhibitor of neuronal sodium channels that interacts with micro conotoxin binding sites.
Mol Pharmacol, 69 : 1931-1937 - 2006 - Moutot N, De Haro L, Santos RG, Mori Y, Seagar M.
Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome.
Neurobiol Dis, 22 : 57-63 - 2006 - Durand J, Amendola J, Bories C, Lamotte d'Incamps B.
Early abnormalities in transgenic mouse models of amyotrophic lateral sclerosis
J Physiol Paris, 99 : 211-220 - 2005 - Ferracci G, Miquelis R, Kozaki S, Seagar M, Lévêque C.
Synaptic vesicle chips to assay botulinum neurotoxins.
Biochem J, 391 : 659-66 - 2004 - Amendola J, Verrier B, Roubertoux B, Durand J.
Altered sensorimotor development in a transgenic mouse model of amyotrophic lateral sclerosis
Eur J Neurosci, 20 : 2822-2826 - 2004 - Moutot N, De Haro L, Seagar M.
[Dosage and specificity of anti-calcium channel antibodies in Lambert-Eaton myasthenic syndrome].
Rev Neurol (Paris), 165 : S28-S34 - 2004 - De Haro L, Ferracci G, Opi S, Iborra C, Quetglas S, Miquelis R, Lévêque C, Seagar M.
Ca2+/calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers.
Proc Natl Acad Sci U S A, 101 : 1578-1583 - 2004 - Ferracci G, Seagar M, Joël C, Miquelis R, Lévêque C.
Real time analysis of intact organelles using surface plasmon resonance.
Anal Biochem, 334 : 367-375 - 2003 - De Haro L, Quetglas S, Iborra C, Lévêque C, Seagar M.
Calmodulin-dependent regulation of a lipid binding domain in the v-SNARE synaptobrevin and its role in vesicular fusion.
Biol Cell, 95 : 459-464 - 2002 - Quetglas S, Iborra C, Sasakawa N, De Haro l, Kumakura K, Sato K, Lévêque C, Seagar M.
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.
EMBO J, 21 : 3970-3979 - 2002 - Dos Santos RG, Van Renterghem C, Moutot N, Mansuelle P, Cordeiro MN, Diniz CR, Mori Y, De Lima ME, Seagar M.
Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites.
J Biol Chem, 277 : 13856-13862 - 2001 - Seagar M, Quetglas S, Iborra C, Lévêque C.
Le complexe SNARE au coeur de la fusion membranaire
Med. Sci, 5 : 669-674 - 2000 - Couraud F, Seagar M.
[Calcium channels and migraine].
Pathol Biol (Paris), 48 : 642-647 - 2000 - Van Renterghem C, Iborra C, Moutot N, Lelianova V, Ushkaryov Y, Seagar M.
alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin.
Eur J Neurosci, 12 : 3953-3962 - 2000 - Quetglas S, Lévêque C, Miquelis R, Sato K, Seagar M.
Ca2+-dependent regulation of synaptic SNARE complex assembly via a calmodulin- and phospholipid-binding domain of synaptobrevin.
Proc Natl Acad Sci U S A, 97 : 9695-9700 - 2000 - Marqueze B, Berton F, Seagar M.
Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?
Biochimie, 82 : 409-420 - 2000 - Berton F, Cornet V, Iborra C, Garrido J, Dargent B, Fukuda M, Seagar M, Marqueze B.
Synaptotagmin I and IV define distinct populations of neuronal transport vesicles.
Eur J Neurosci, 12 : 1294-1302 - 2000 - Lévêque C, Boudier JA, Takahashi M, Seagar M.
Calcium-dependent dissociation of synaptotagmin from synaptic SNARE complexes.
J Neurochem, 74 : 367-374 - 2000 - Sampo B, Tricaud N, Lévêque C, Seagar M, Couraud F, Dargent B.
Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels.
Proc Natl Acad Sci U S A, 97 : 3666-3671 - 1999 - Raymond C, Walker D, Bichet D, Iborra C, Moutot N, Seagar M, De Waard M.
Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome.
Neuroscience, 90 : 269-277 - 1999 - Boudier JA, Moutot N, Boudier JL, Iborra C, Takahashi M, Seagar M.
Redistribution of presynaptic proteins during alpha-latrotoxin-induced release of neurotransmitter and membrane retrieval at the frog neuromuscular junction.
Eur J Neurosci, 11 : 3449-3456 - 1999 - Seagar M, Lévêque C, Charvin N, Marqueze B, Moutot N, Boudier JA, Boudier JL, Shoji-Kasai Y, Sato K.
Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.
Philos Trans R Soc Lond B Biol Sci, 354 : 289-297 - 1998 - Seagar M, Takahashi M.
Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis.
J Bioenerg Biomembr, 30 : 347-356 - 1998 - Lévêque C, Pupier S, Marqueze B, Geslin L, Kataoka M, Takahashi M, De Waard M, Seagar M.
Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel.
J Biol Chem, 273 : 13488-13492 - 1998 - Seagar M, Lévêque C, Charvin N, Marqueze B, Moutot N, Boudier JA, Boudier JL, Kataoka M, Shoji-Kaisai Y, Takahashi M.
Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.
Eur J Neurosci, 10 : 12501 - 1997 - Pupier S, Lévêque C, Marqueze B, Kataoka M, Takahashi M, Seagar M.
Cysteine string proteins associated with secretory granules of the rat neurohypophysis.
J Neurosci, 17 : 2722-2727 - 1997 - Charvin N, Lévêque C, Walker D, Berton F, Raymond C, Kataoka M, Shoji-Kasai Y, Takahashi M, De Waard M, Seagar M.
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.
EMO J, 16 : 4591-4596 - 1997 - Berton F, Iborra C, Boudier JA, Seagar M, Marqueze B.
Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS.
J Neurosci, 17 : 1206-1216 - 1996 - Boudier JA, Charvin N, Boudier JL, Fathallah M, Tagaya M, Takahashi M, Seagar M.
Distribution of components of the SNARE complex in relation to transmitter release sites at the frog neuromuscular junction.
Eur J Neurosci, 8 : 545-552 - 1996 - Moutot N, Charvin N, Lévêque C, Sato K, Nishiki T, Kozaki S, Takahashi M, Seagar M.
Interaction of SNARE complexes with P/Q-type calcium channels in rat cerebellar synaptosomes.
J Biol Chem, 271 : 6567-6570 - 1996 - Arsac C, Raymond C, Moutot N, Dargent B, Couraud F, Poget J, Seagar M.
Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum.
Ann Neurol, 40 : 695-700 - 1995 - Marqueze B, Boudier JA, Mizuta M, Inagaki M, Seino S, Seagar M.
Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat.
J Neurosci, 15 : 4906-4917 - 1995 - Kim JI, Takaashi M, Moutot N, Seagar M, Ohtake A, Sato K.
Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel.
Biochem Biophys Res Commun, 214 : 305-309 - 1995 - Moutot N, Lang B, Newsom-Davis J, Seagar M.
Binding of Lambert-Eaton myasthenic syndrome IgG to synaptosomal proteins does not correlate with an inhibition of calcium uptake.
Neurosci Lett, 187 : 11(-118 - 1995 - Seagar M, Moutot N, Lévêque C, Marqueze B, Pouget J.
Anti-calcium channel autoantibodies in amyotrophic lateral sclerosis. A review of the evidence.
Adv Neurol, 68 : 67-72 - 1995 - El Far O, Marqueze B, Lévêque C, Moutot N, Lang B, Newsom-Davis J, Yoshida A, Takahashi M, Seagar M.
Antigens associated with N- and L-type calcium channels in Lambert-Eaton myasthenic syndrome.
J Neurochem, 64 : 1696-1702 - 1995 - Moutot N, Lévêque C, Sato K, Kato R, Takahashi M, Seagar M.
Properties of omega conotoxin MVIIC receptors associated with alpha 1A calcium channel subunits in rat brain.
FEBS Lett, 366 : 21-25 - 1995 - El Far O, Charvin N, Lévêque C, Moutot N, Takahashi M, Seagar M.
Interaction of a synaptobrevin (VAMP)-syntaxin complex with presynaptic calcium channels.
FEBS Lett, 361 : 101-105 - 1994 - Lévêque C, El Far O, Moutot N, Sato K, Kato R, Takahashi M, Seagar M.
Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.
J Biol Chem, 269 : 6306-6312 - 1993 - Moutot N, El Far O, Lévêque C, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin: a Lambert-Eaton myasthenic syndrome antigen that associates with presynaptic calcium channels.
J Physiol Paris, 87 : 37-41 - 1993 - Grignon S, Seagar M, Couraud F.
Omega-conotoxin sensitive calcium channels in cerebellar granule cells are not coupled to [3H]glutamate release.
Neurosci Lett, 155 : 8è-91 - 1993 - El Far O, Moutot N, Lévêque C, David P, Marqueze B, Lang B, Newom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin associates with presynaptic calcium channels and is a Lambert-Eaton myasthenic syndrome antigen.
Ann N Y Acad Sci, 707 : 382-385 - 1993 - David P, Moutot N, Lévêque C, El Far O, Takahashi M, Seagar M.
Interaction of synaptotagmin with voltage gated calcium channels: a role in Lambert-Eaton myasthenic syndrome?
Neuromuscul Disord, 3 : 451-454 - 1993 - David P, El Far O, Moutot N, Poupon MF, Takahashi M, Seagar M.
Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.
FEBS Lett, 326 : 135-139 - 1993 - Seagar M, Moutot N, Lévêque C, El Far O, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M.
A Lambert-Eaton myasthenic syndrome antigen associated with presynaptic calcium channels.
Biochem Soc Trans, 21 : 423-428 - 1993 - McEnery MW, Snowman AM, Seagar M, Copeland TD, Takahashi M.
Immunological characterization of proteins associated with the purified omega-conotoxin GVIA receptor.
Ann N Y Acad Sci, 707 : 386-391 - 1992 - Lévêque C, Hoshino T, David P, Shoji-Kasai Y, Leys K, Omori A, Lang B , El Far O, Sato K, Newsom-Davis J, Takahashi M, Moutot N, Seagar M.
The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen.
Proc Natl Acad Sci U S A, 89 : 3625-3629 - 1992 - De Waard M, Seagar M, Feltz A, Couraud F.
Inositol phosphate regulation of voltage-dependent calcium channels in cerebellar granule neurons.
Neuron, 9 : 497-503 - 1988 - Marqueze B, Moutot N, Lévêque C, Couraud F.
Characterization of the omega-conotoxin-binding molecule in rat brain synaptosomes and cultured neurons.
Mol Pharmacol, 34 : 87-90
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