PUBLICATIONS Search by author : All authorsAlcaraz GAmendola JAnkri NAziz AAzzaz FBaudot PBialowas ABoudkkazi SBoumedine NBrechet ACaillard OCampanac ECarlier EChahinian HCoq JOCudmore RHDaoudal GDe San Feliciano MDebanne DDebreux KDenis DDesplantes RDi Giovanni JDubruc FDufour MDuménieu MDéglise PEl Far OExtrémet JFantini JFormisano-Treziny CFronzaroli-Molinieres LFékété AGabert JGasselin CGastrein PGiraud PGoaillard JMHaddjeri-Hopkins AIborra CIncontro SInglebert YLEVEQUE CLopez CLévêque CMarcaggi PMarqueze BMarra VMaulet YMoubarak EMoutot NRama SRamirez-Franco JJRussier MSammari MSangiardi MSeagar MSourdet VTapia MTell FTemporal SUsseglio FWakade AWoodhouse AYahi NYoussouf FZanin EZbili M Search by year of publication : All years2023202220212020201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990198919881987198619841983198219811980197919781974 Search by key word :
	PUBLICATIONS HOME PAGE   |  PUBLICATIONS YEAR : 2011 A role for V-ATPase subunits in synaptic vesicle fusion? AUTHORS : El Far O, Seagar M. JOURNAL : Journal of Neurochemistry N° Pubmed : 21375531 SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors)-mediated exocytotic release of neurotransmitters is a key process in neuronal communication, controlled by a number of molecular interactions. A synaptic vesicle v-SNARE protein (VAMP2 or synaptobrevin), in association with two plasma membrane t-SNAREs (syntaxin 1 and SNAP25), assemble to form a protein complex that is largely accepted as the minimal membrane fusion machine. Acidification of the synaptic vesicle lumen by the large multi-subunit vacuolar proton pump (V-ATPase) is required for loading with neurotransmitters. Recent data demonstrate a direct interaction between the c-subunit of the V-ATPase and VAMP2 that appears to play a role at a late step in transmitter release. In this review, we examine evidence suggesting that the V0 membrane sector of the V-ATPase not only participates in proton pumping, but plays a second distinct role in neurosecretion, downstream of filling and close to vesicle fusion. Haut de page

UMR 1072, Boulevard Pierre Dramard, 13015 Marseille - 04 91 69 89 43 - Création : E-Partenaire