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BIOSKETCH
I started the "Homeostasis of Excitability and Neuromodulation" group in 2007. Previously I was a post-doctoral fellow in Eve Marder's lab at Brandeis University (Waltham, MA, USA) where I studied the impact of co-variations in ion channel properties on the functional output of the crustacean stomatogastric network. My PhD work was performed under the supervision of Pierre Vincent (Université Pierre et Marie Curie, Paris). We combined for the first time cAMP fluorescence imaging with patch-clamp recordings to investigate the modulation of voltage-gated ion channels by cAMP. Before obtaining my PhD in Paris, I studied in Montpellier (south of France, mediterranean coast) and in Pau (south of France, close to the Pyrénées).
FORMER LABS
2002/2006 "Modulation of Neural Networks", Eve Marder, Brandeis University, Waltham, MA, USA Postdoctoral Fellow
1998/2002 "Neurobiology of Adaptative Processes", UPMC, Paris, FRANCE PhD Student (PhD advisor: Pierre Vincent)
1997/1998 "UNIC", Institut de Neurosciences Alfred Fessard, Gif sur Yvette, FRANCE Master Student (Advisor: Nicole Ropert)
LINKS
In addition to the labs I visited during my short career (above), here are the links to a few labs performing great work in Neuroscience :
- Dirk Bucher's lab (Whitney Laboratory for Marine Bioscience, St. Augustine, FA, USA). Crustacean stomatogastric nervous system, dynamics of axonal function. Electrophysiology, anatomy.
- David Schulz's lab (University of Missouri, Columbia, MO, USA). Crustacean stomatogastric nervous system (and other), co-regulation of ion channels, homeostasis of excitability. Electrophysiology, molecular biology.
- Stefan Pulver (Janelia Farm Research Campus, Ashburn, VA, USA). Locomotor rhythms in the drosophila crawling larva (the maggott). Imaging.
- Jeremy Niven's lab (University of Sussex, Brighton, UK). Evolution of nervous systems, with an emphasis on invertebrates. Electrophysiology, modelling.
- Harold Zakon's lab (University of Texas at Austin, Austin, TX, USA). Neuroethology of electrical communication in the weakly electric fish. Electrophysiology, modelling.
PUBLICATIONS :- 2021 - Goaillard JM, Marder E.
Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience Annual Review of Neuroscience, 44 : 335-357 - 2021 - Haddjeri-Hopkins A, Tapia M, Ramirez-Franco JJ, Tell F, Marqueze B, Amalric M, Goaillard JM.
Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons eNeuro - 2020 - Goaillard JM, Moubarak E, Tapia M, Tell F.
Diversity of axonal and dendritic contributions to neuronal output Frontiers in Cellular Neuroscience, 13 : 570 - 2019 - Moubarak E, Engel D, Dufour M, Tapia M, Tell F, Goaillard JM.
Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons. Journal of Neuroscience, 39 : 5044-5063 - 2019 - Baudot P, Goaillard JM, Bennequin D, Tapia M.
Topological Information Data Analysis Entropy, 21 - 2018 - Tapia M, Baudot P, Formisano-Treziny C, Dufour M, Temporal S, Lasserre M, Marqueze B, Gabert J, Kobayashi K, Goaillard JM.
Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons Scientific Reports, 8 : 13637 - 2015 - Hammond C, Debanne D, Goaillard JM.
Somato-dendritic processing of postsynaptic potentials II. Role of sub-threshold depolarizing voltage-gated currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D.
Somato-dendritic processing of postsynaptic potential III. Role of high-voltage-activated depolarizing currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D, Gaiarsa JL.
Synaptic plasticity Cellular and molecular neurophysiology - 2014 - Goaillard JM, Dufour M.
The pros and cons of degeneracy Elife, 3 : e02615 - 2014 - Dufour M, Woodhouse A, Goaillard JM.
Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development Journal of Neuroscience Research, 92 : 981-999 - 2014 - Mlayah-Bellalouna S, Dufour M, Mabrouk S, Mejdoub, H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.
AaTX1, from Androctonus australis scorpion venom: Purification, synthesis and characterization in dopaminergic neurons Toxicon, 92 : 14-23 - 2014 - Marqueze B, Mailfert S, Rouger V, Goaillard JM, Marguet D.
Physiological epidermal growth factor concentrations activate high affinity receptors to elicit calcium oscillations PLoS One, 29 : e106803 - 2014 - Dufour M, Woodhouse A, Amendola J, Goaillard JM.
Non-linear developmental trajectory of electrical phenotype in rat substantia nigra pars compacta dopaminergic neurons eLife, 2014 Oct 20 - 2012 - Amendola J, Woodhouse A, Martin-Eauclaire MF, Goaillard JM.
Ca²⁺/cAMP-sensitive covariation of I(A) and I(H) voltage dependences tunes rebound firing in dopaminergic neurons Journal of Neuroscience, 32 : 125-132 - 2012 - Goaillard JM, Groc L, Lévi S, Mantegazza M, Matifat F, Morel JL, Baron-Forster A.
The 22nd ion channel meeting, september 2011, france Channels (Austin), 6 : 149-153 - 2011 - Bucher D, Goaillard JM.
Beyond faithful conduction: short-term dynamics, neuromodulation, and long-term regulation of spike propagation in the axon Progress in Neurobiology, 94 : 307-346 - 2011 - Goaillard JM.
Neural networks: more about flexibility than synaptic strength Current Biology, 21 : R276-278 - 2010 - Goaillard JM, Taylor AL, Pulver SR, Marder E.
Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism Journal of Neuroscience, 30 : 4687-4692 - 2010 - Goaillard JM.
Immature brains don't need GABA to get 'hyper'-excited. Journal of Physiology, 588 : 7-8 - 2009 - Goaillard JM, Taylor AL, Schulz DJ, Marder E.
Functional consequences of animal-to-animal variation in circuit parameters Nature Neuroscience, 12 : 1424-1430 - 2009 - Taylor AL, Goaillard JM, Marder E.
How multiple conductances determine electrophysiological properties in a multicompartment model Journal of Neuroscience, 29 : 5573-5586 - 2007 - Schulz DJ, Goaillard JM, Marder E.
Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression Proc Natl Acad Sci U S A, 104 : 13187-13191 - 2007 - Cudmore RH, Goaillard JM, Debanne D.
Inhibition facilitates depression. Journal of Physiology (London), 585 : 323 - 2006 - Marder E, Goaillard JM.
Variability, compensation and homeostasis in neuron and network function Nature Reviews Neuroscience, 7 : 563-574 - 2006 - Goaillard JM, Marder E.
Dynamic-clamp analyses of cardiac, endocrine and neural function Physiology (Bethesda), 21 : 197-207 - 2006 - Schulz DJ, Goaillard JM, Marder E.
Variable channel expression in identified single and electrically coupled neurons in different animals. Nature Neuroscience, 9 : 356-362 - 2006 - Le T, Verley DR, Goaillard JM, Messinger DI, Christie AE, Birmingham JT.
Bistable behavior originating in the axon of a crustacean motor neuron. Journal of Neurophysiology, 95 : 1356-1368 - 2004 - Goaillard JM, Schulz DJ, Kilman VL, Marder E.
Octopamine modulates the axons of modulatory projection neurons. Journal of Neuroscience, 24 : 7063-7073 - 2003 - Goaillard JM, Marder E.
Exciting guts with GABA Nature Neuroscience, 6 : 1121-1122 - 2002 - Goaillard JM, Vincent P.
Serotonin suppresses the slow afterhyperpolarization in rat intralaminar and midline thalamic neurones by activating 5-HT(7) receptors. Journal of Physiology, 541 : 453-465 - 2002 - Laurent A, Goaillard JM, Cases O, Lebrand C, Gaspar P, Ropert N.
Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice. Journal of Neuroscience, 22 : 886-900 - 2001 - Goaillard JM, Vincent P, Fischmeister R.
Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes. Journal of Physiology, 530 : 79-91
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