RESEARCH TOPIC :
Since the creation of the team, we explore 6 research lines in parallel: 1) synaptic plasticity (Inglebert et al., PNAS 2020; Ho et al., PNAS 2021; Debanne & Inglebert, Curr Opin Neurobiol 2023), 2) plasticity of intrinsic neuronal excitability in hippocampal (Daoudal et al., PNAS 2002; Campanac & Debanne, J Physiol 2008; Campanac et al., J Neurosci 2008; Cudmore et al., J Neurosci 2010; Campanac et al., Neuron 2013; Gasselin et al., J Physiol 2015; Gasselin et al., Sci Rep 2017; Debanne et al., Curr Opin Neurobiol 2019; Incontro et al., J Neurosci 2021; Sammari et al., PNAS 2022), and neocortical neurons ((Sourdet et al., J Neurosci 2003; Carlier et al., J Physiol 2006), 3) synaptic and intrinsic factors controling neuronal timing ((Sourdet et al., J Neurosci 2003; Boudkkazi et al., Neuron 2007; Cudmore et al., J Neurosci 2010; Boudkkazi et al., J Physiol 2011; Gastrein et al., J Physiol 2011; Caillard PLoS One 2011; Dubruc et al., J Neurophysiol 2013), 4) synaptic and intrinsic properties of extra-ocular (abducens) motoneurones (Russier et al., J Physiol 2002; Russier et al., J Physiol 2003), 5) axonal function (Kopysova & Debanne, J Neurosci 1998; Bialowas et al., EJN 2015; Rama et al., Nat Commun 2015; Rama et al., Sci Rep 2017; Zbili & Debanne, Front Cell Neurosci 2020; Zbili et al., Sci Adv 2020; Fékété et al., PNAS 2021; Zbili et al., PNAS 2021). 6) role of LGI1 protein in the tuning of neuronal excitability (Seagar et al., PNAS 2017; Ramirez-Franco et al., Brain 2022; Extrémet et al., Cells 2022) We explore 4 main research themes in parallel: 1) plasticity of intrinsic neuronal excitability, 2) synaptic plasticity, 3) axon function and 4) LGI1 and neuronal excitability.
PROJECTS : Intrinsic plasticity Long-lasting plasticity of synaptic transmission is classically thought to be the cellular substrate for information storage in the brain. Recent data indicate however that it is not the whole story and persistent changes in the intrinsic neuronal excitability have been shown to occur in parallel to the induction of long-term synaptic modifications. A large part of our research activity is devoted to the characterization of interactions existing between synaptic and intrinsic plasticity. We have established that learning rules defined for synaptic transmission (BCM, STDP) are also valid for plasticity of dendritic integration in CA1 pyramidal neurons (Daoudal et al., PNAS 2002; Campanac & Debanne, J Physiol 2008). We show that h-channel activity is reduced in the dendrites following induction of potentiation of dendritic integration (Campanac et al., J Neurosci 2008). We demonstrate for the first time that GABAergic interneurons also express plasticity of intrinsic neuronal excitability (Campanac et al. Neuron 2013; Incontro et al., J Neurosci 2021; Sammari et al., PNAS 2022). We have identified the role of HCN channels in the homeostatic regulation of intrinsic excitability in CA1 neurons (Gasselin, et al., J Physiol 2015; Gasselin et al., Sci Rep 2017). We are now exploring i) the mechanisms of activity-dependent regulation of Kv1 channels (ANR Blanc Neuroscience 2011 Reprek), ii) the mechanisms underlying intrinsic plasticity induced in parallel with synaptic LTD and iii) the role of intrinsic plasticity in amblyopia (FRM Physiopathology of the visual system 2013; ANR Plastinex 2021).
Neuronal timing We explore the factors determining neuronal synchronization at 2 strategic points of the neuron: the synapse and the axon initial segment. We have established that the synaptic delay is not constant but rather depends on release probability (Boudkkazi et al., Neuron 2007) and presynaptic spike waveform (Boudkkazi et al., J Physiol 2011). Thus, synaptic delay is modified during several forms of short- and long-term synaptic plasticity. We have also demonstrated the role of voltage trajectories preceding the spike in temporal precision of spike firing (Sourdet et al., J Neurosci 2003; Cudmore et al., J Neurosci 2010; Gastrein et al., J Physiol 2011). These voltage trajectories are finely tuned by many voltage-gated ionic currents that specifically affect the first action potential (D-type current meidate by Kv1 channels or H-type cationic current) or secondary action potentials (mAHP current meidated by SK channels). We also explore the role of inhibitory synaptic activity in the precision of neuronal discharge (Caillard, PLoS One 2011; Dubruc et al., J Neurophysiol 2013).
Axon Finally, our work also examines how voltage-gated ion channels in the axon determine information processing in hippocampal and neocortical circuits (Debanne et al. Nature 1997; Kopysova & Debanne, J Neurosci 1998; Debanne, Nat Rev Neurosci 2004; Debanne et al., Physiol Rev 2011). Our project is aimed at determining the axonal mechanisms of analog-digital modification of synaptic strength (Debanne et al., Nat Rev Neurosci 2013; Bialowas et al. EJN 2015; Rama et al., Nat Commun 2015; Zbili et al., Sci Adv 2020) and the role of axonal Kv1 channels on intrinsic excitability measured in the cell body (Rama et al., Sci Rep 2017).
LGI1 and epilepsy We have shown that the lack of LGI1 protein increased neuronal excitability and transmitter release through a reduction of the DTX-sensitive current, thus accounting for the epilepsy observed in patient lacking LGI1 (Seagar et al., PNAS 2017). We have shown that antibodies against the LRR region but not against the EPTP region increased excitability in CA3 neurons (Extrémet et al., Cells 2022).
COLLABORATIONS Internal: Oussama El Far (ANR Blanc Biologie Cellulaire 2011 MOMENT; FRM 2013). Local: Service de biochimie et biologie moléculaire CHU Nord (Pr J Gabert; FRM 2013), Service d'ophtalmologie (Pr D Denis; FRM 2013) National: JC Poncer (INSERM Paris; ANR NMP 2008 EPISOM), Agnès Baude (INSERM, Marseille), Stéphanie Baulac (INSERM, Paris; ANR Blanc Neurosciences 2011, REPREK), Romain Brette (Institut de la Vision, Paris; ANR Axode 2014-2017) & Boris Barbour (IBENS Paris; NSF-ANR Syncity 2014) International: JJ Garrido (CSIC, Madrid) & Nicolas Brunel (Chicago, USA; NSF-ANR Syncity 2014)
METHODS Our group uses all the electrophysiological methods in vitro (acute slices of brain tissue and organotypic slice cultures of hippocampus). We have 6 patch-clamp rigs mostly equipped with fluorescent cameras and multiple micromanipulators to allow simultaneous recording from the same neuron (soma/dendrite (Campanac et al., J Neurosci 2008), or soma/axon (Boudkkazi et al., Neuron 2007; Boudkkazi et al., 2011; Rama et al., 2015) or synaptic recording from pairs of connected neurons (Boudkkazi et al., Neuron 2007; Debanne et al., Nat Prot 2008; Boudkkazi et al., J Physiol 2011; Gastrein et al., J Physiol 2011; Rama et al., Nat Commun 2015; Zbili et al., Sci Adv 2020). One patch clamp set-up is equipped with a confocal microscope (LSM710 Zeiss) which allows us to combine high resolution imaging of calcium, sodium and voltage with electrophysiological recording on acute slices or cultures (Bialowas et al., EJN 2015; Rama, Front Cell Neurosci 2015; Rama et al., Nat Commun 2015; Rama et al., Sci Rep 2017; Zbili et al., Sci Adv 2020; Inglebert et al., PNAS 2020; Fékété et al., PNAS 2021). We also use modeling and hybrid techniques (dynamic-clamp (Sourdet et al. J Neurosci 2003; Cudmore et al. J Neurosci 2010; Rama et al., 2015; Zbili et al., 2020; Fékété et al., 2021) and hybrid networks (Cudmore et al., J Neurosci 2010)) to identify the functional consequences of intrinsic plasticity.
FUNDING : Our group is supported by INSERM, CNRS, Ministère de la Recherche, Fondation Recherche Médicale, European Community, Agence Nationale de la Recherche, Ecole Normale Supérieure, Institut Méditerranéen de Recherche Avancée (IMéRA) and Région PACA
Current grants: FRM Equipe 2019-2023 ANR PLASTINEX 2021-2025 Région SUD "DESOMLIBEX" 2021-2024 A*Midex, Equipment 2023-2025 FRC, Molecular mechanisms of visual thalamus plasticity, 2023-2024 A*Midex, Release of somatostatine by interneurons 2024-2026 ANR, "SYNCHROSYN" Régulation de la transmission synaptique dépendante de la synchronie, 2023-2027
FORMER MEMBERS :
ALCARAZ Gisèle, BIALOWAS Andrzej , BOUDKKAZI Sami, CAILLARD Olivier , CAMPANAC Emilie, CARLIER Edmond , COQ Olivier , CUDMORE Robert H, DAOUDAL Gaël, DEGLISE Patrice, DUBRUC Franck , DUMENIEU Maël, EXTREMET Johanna, FEKETE Aurélie, GASSELIN Célia , GASTREIN Philippe, GIRAUD Pierre , GOAILLARD Jean-Marc , INGLEBERT Yanis, MARRA Vincenzo , PIERALI Hélia, RAMA Sylvain , SAMMARI Malika, SOURDET Valérie, WAKADE Anushka, ZANIN Emilie, ZBILI Mickaël.
PUBLICATIONS :
- 2023 - Debanne D, Inglebert Y.
Spike timing-dependent plasticity and memory Current Opinion in Neurobiology, 80 : 102707 - 2023 - Ankri N, Debanne D.
A fast Markovian method for modeling channel noise in neurons Helyion, 9 : e16953 - 2023 - Duménieu M, Fronzaroli-Molinieres L, Iborra C, Wakade A, Zanin E, Aziz A, Ankri N, Incontro S, Denis D, Brette R, Marqueze B, Debanne D, Russier M.
Visual activity enhances neuronal excitability in thalamic relay neurons BioRxiv - 2023 - Extrémet J, Ramirez-Franco JJ, Fronzaroli-Molinieres L, Boumedine N, Ankri N, El Far O, Garrido JJ, Debanne D, Russier M.
Rescue of normal excitability in LGI1-deficient epileptic neurons Journal of Neuroscience, 43 - 2022 - Ramirez-Franco JJ, Debreux K, Extrémet J, Maulet Y, Belghazi M, Villard C, Sangiardi M, Youssouf F, El Far L, Lévêque C, Debarnot C, Marchot P, , Debanne D, Russier M, Seagar M, Irani S, El Far O.
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 Brain, doi: 10.1093/brain/awac218 - 2022 - Extrémet J, El Far O, Ankri N, Irani SR, Debanne D, Russier M.
An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel Cells, 11 : 2713 - 2022 - Sammari M, Inglebert Y, Ankri N, Russier M, Incontro S, Debanne D.
Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons Proceedings of the National Academy of Sciences USA, 119 : e2205264119 - 2021 - Fékété A, Ankri N, Brette R, Debanne D.
Neural excitability increases with axonal resistance between soma and axon initial segment Proceedings of the National Academy of Sciences USA, 118 : e2102217118 - 2021 - Inglebert Y, Debanne D.
Calcium and spike timing-dependent plasticity Frontiers in Cellular Neuroscience, 15 : 727336 - 2021 - Zhang W, Ciorraga M, Mendez P, Retana D, Boumedine N, Achon B, Russier M, Debanne D, Garrido JJ.
Formin activity and mDia1 contribute to maintain axon initial segment composition and structure Molecular Neurobiology : doi: 10.1007/s12035-021-02531-6 - 2021 - Incontro S, Sammari M, Azzaz F, Inglebert Y, Ankri N, Russier M, Fantini J, Debanne D.
Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of post-synaptic Kv7 channels Journal of Neuroscience, 41 : 9521-9538 - 2021 - Ho S, Lajaunie R, Lerat M, Le M, Crépel V, Loulier K, Livet J, Kessler JP, Marcaggi P.
A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation Proceedings of the National Academy of Sciences USA, 118 : e2024890118 - 2021 - Duménieu M, Marqueze B, Russier M, Debanne D.
Mechanisms of plasticity in subcortical visual areas Cells, 10 : 3162 - 2021 - Zbili M, Rama S, Benitez MJ, Fronzaroli-Molinieres L, Bialowas A, Boumedine N, Garrido JJ, Debanne D.
Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit Proceedings of the National Academy of Sciences USA, 118 : e2110601118 - 2020 - Zbili M, Rama S, Yger P, Inglebert Y, Boumedine N, Fronzaroli-Molinieres L, Brette R, Russier M, Debanne D.
Axonal Na+ channels detect and transmit levels of input synchrony in local brain circuits Science Advances, 6 : eaay4313 - 2020 - Zbili M, Debanne D.
Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study. Frontiers in Cellular Neuroscience, 14 : 40 - 2020 - Kamiya H, Debanne D.
Editorial: Axon neurobiology: fine scale dynamics of microstructure and function Frontiers in Cellular Neuroscience, 14 : 594361 - 2020 - Inglebert Y, Aljadeff J, Brunel N, Debanne D.
Synaptic plasticity rules with physiological calcium levels Proceedings of the National Academy of Sciences USA, 117 : 33639-33648 - 2019 - Debanne D, Inglebert Y, Russier M.
Plasticity of intrinsic neuronal excitability Current Opinion in Neurobiology, 54 : 73-82 - 2019 - Rama S, Boumedine N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne D, El Far O.
Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification Molecular Neurobiology, 56 : 3591-3602 - 2019 - Zbili M, Debanne D.
Past and future of analog-digital modulation of synaptic transmission Frontiers in Cellular Neuroscience, 13 : 160 - 2019 - Debanne D, Russier M.
The contribution of ion channels in input-output plasticity Neurobiology of Learning and Memory, 166 : 107095 - 2019 - Steidl E, Gleyzes M, Maddalena F, Debanne D, Buisson B.
Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds Journal of Pharmacological and Toxicological Methods, in press - 2018 - Delcour M, Massicotte VS,, Russier M, Bras H, Peyronet J, Canu MH, Barbe MF, Coq JO.
Early movement restriction leads to enduring disorders in muscle and locomotion Brain Pathology, (in press) - 2018 - Rama S, Zbili M, Debanne D.
Signal propagation along the axon Current Opinion in Neurobiology, 51 : 37-44 - 2018 - Fékété A, Debanne D.
Somatic modulation of ectopic action potential initiation in distal axons Journal of Physiology (London), 596 : 5067-5068 - 2018 - Debanne D, El Far O.
Pre- and post-synaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis Brain, 141 : 3092-3095 - 2018 - Debanne D, Garrido J.
Axon initial segment Encyclopedia of Life Sciences : a00004 - 2018 - Delcour M, Russier M, Castets F, Turle-Lorenzo N, Canu MH, Cayetanot F, Barbe MF, Coq JO.
Early movement restriction leads to maladaptive plasticity in the sensorimotor cortex and to movement disorders Scientific Reports, 8 : 16328 - 2017 - Rama S, Zbili M, Fékété A, Tapia M, Benitez MJ, Boumedine N, Garrido JJ, Debanne D.
The role of axonal Kv1 channels in CA3 pyramidal cell excitability Scientific Reports, 7 : 315 - 2017 - Debanne D, Russier M.
How do electrical synapses regulate their strength? Journal of Physiology (London), 595 : 4121-4122 - 2017 - Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine N, Rodriguez L, Zbili M, Usseglio F, Formisano-Treziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne D, , El Far O.
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels Proceedings of the National Academy of Sciences USA, 114 : 7719-7724 - 2017 - Gasselin C, Inglebert Y, Ankri N, Debanne D.
Plasticity of intrinsic excitability during LTD is mediated by bidirectional changes in h-channel activity Scientific Reports, 7 : 14418 - 2016 - Zbili M, Rama S, Debanne D.
Dynamic control of neurotransmitter release by presynaptic potential Frontiers in Cellular Neuroscience, 10 : 278 - 2015 - Del Puerto, Fronzaroli-Molinieres L, Perez-Alvarez MJ, Giraud P, Carlier E, Wandosell, F, Debanne D, Garrido, JJ.
ATP-P2X7 Receptor Modulates Axon Initial Segment Composition and Function in Physiological Conditions and Brain Injury Cerebral Cortex, 25 : 2282-2294 - 2015 - Bialowas A, Rama S, Zbili M, Marra V, Fronzaroli-Molinieres L, Ankri N, Carlier E, Debanne D.
Analog modulation of spike-evoked transmission in CA3 circuits is determined by Kv1.1 channels in a time-dependent manner European Jounral of Neuroscience, 41 : 293-304 - 2015 - Rama S, Zbili M, Debanne D.
Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels Biochimica et Biophysica Acta (BBA)- Molecular Cell Research, 1853 : 1933-1939 - 2015 - Gasselin C, Inglebert Y, Debanne D.
Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons Journal of Physiology (London), 593 : 4855-4869 - 2015 - Rama S, Zbili M, Bialowas A, Fronzaroli-Molinieres L, Ankri N, Carlier E, Marra V, Debanne D.
Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels Nature Communications, 6 : 10163 - 2015 - Rama S.
Shift and Mean Algorithm for Functional Imaging with High Spatio-Temporal Resolution Frontiers in Cellular Neuroscience, 9 : 446 - 2015 - Hammond C, Debanne D, Goaillard JM.
Somato-dendritic processing of postsynaptic potentials II. Role of sub-threshold depolarizing voltage-gated currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D.
Somato-dendritic processing of postsynaptic potential III. Role of high-voltage-activated depolarizing currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D, Gaiarsa JL.
Synaptic plasticity Cellular and molecular neurophysiology - 2014 - Debanne D, Campanac E.
Memory (mechanisms other than LTP) Encyclopedia of Life Sciences - 2014 - Mlayah-Bellalouna S, Dufour M, Mabrouk S, Mejdoub, H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.
AaTX1, from Androctonus australis scorpion venom: Purification, synthesis and characterization in dopaminergic neurons Toxicon, 92 : 14-23 - 2013 - Debanne D, Bialowas A, Rama S.
What are the mechanisms for analog and digital signaling in the brain? Nature Reviews Neuroscience, 14 : 63-69 - 2013 - Tapia M, Del Puerto A, Puime A, Sánchez-Ponce D, Fronzaroli-Molinieres L, Pallas-Bazarra N, Carlier E, Giraud P, Debanne D, Wandossell F, Garrido JJ.
GSK3 and β-catenin determine functional expression of sodium channels at the axon initial segment Cellular and Molecular Life Sciences, 70 : 105-120 - 2013 - Campanac E, Gasselin C, Baude A, Rama S, Ankri N, Debanne D.
Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits Neuron, 77 : 712-722 - 2013 - Dubruc F, Dupret D, Caillard O.
Self-tuning of inhibition by endocannabinoids shapes spike-time precision in CA1 pyramidal neurons Journal of Neurophysiology, 110 : 1930-1944 - 2011 - Debanne D, Rama S.
Astrocytes shape axonal signaling. Science Signaling, 4 : pe11 - 2011 - Gastrein P, Campanac E, Gasselin C, Cudmore RH, Bialowas A, Carlier E, Fronzaroli-Molinieres L, Debanne D.
The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro. Journal of Physiology (London), 589 : 3753-3773 - 2011 - Debanne D.
The nodal origin of intrinsic bursting Neuron, 71 : 569-570 - 2011 - Debanne D, Campanac E, Bialowas A, Carlier E, Alcaraz G.
Axon physiology Physiological Reviews, 91 : 555-602 - 2011 - Boudkkazi S, Fronzaroli-Molinieres L, Debanne D.
Presynaptic action potential waveform determines cortical synaptic latency Journal of Physiology (London), 589 : 1117-1131 - 2011 - Caillard O.
Pre & postsynaptic tuning of action potential timing by spontaneous GABAergic activity. PLoS One, 6 : e22322 - 2011 - Baaken G, Ankri N, Schuler AK, Rühe J, Behrends J.
Nanopore-based single-molecule mass spectrometry on a lipid membrane microarray. ACS Nano, 5 : 8080-8088 - 2011 - Gaudioso C, Carlier E, Youssouf F, Clare JJ, Debanne D, Alcaraz G.
Calmodulin and calcium differentially regulate the neuronal Nav1.1 voltage-dependent sodium channel. Biochem Biophys Res Commun, 411 : 329-334 - 2010 - Di Giovanni J, Boudkkazi S, Mochida S, Bialowas A, Samari N, Lévêque C, Youssouf F, Brechet A, Iborra C, Maulet Y, Moutot N, Debanne D, Seagar M, El Far O.
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release. Neuron, 67 : 268-279 - 2010 - Cudmore RH, Fronzaroli-Molinieres L, Giraud P, Debanne D.
Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current. Journal of Neuroscience, 30 : 12885-12895 - 2010 - Caillard O, Debanne D.
Cell-specific contribution to gamma oscillations. Journal of Physiology (London), 588 : 751 - 2010 - Debanne D, Poo MM.
Spike-timing dependent plasticity beyond synapse - pre- and post-synaptic plasticity of intrinsic neuronal excitability. Frontiers in Synaptic Neuroscience, 2 : 21 - 2010 - Froemke RC, Debanne D, Bi GQ.
Temporal modulation of spike-timing-dependent plasticity. Frontiers in Synaptic Neuroscience, 2 : 19 - 2009 - Debanne D, Campanac E.
Memory: mechanisms other than LTP Encyclopedia of Life Sciences - 2009 - Debanne D.
Plasticity of neuronal excitability in vivo Journal of Physiology (London), 587 : 3057-3058 - 2008 - Debanne D, Boudkkazi S, Campanac E, Cudmore RH, Giraud P, Fronzaroli-Molinieres L, Carlier E, Caillard O.
Paired-recordings from synaptically coupled cortical and hippocampal neurons in acute and cultured brain slices. Nature Protocols, 3 : 1559-1568 - 2008 - Campanac E, Daoudal G, Ankri N, Debanne D.
Downregulation of dendritic I(h) in CA1 pyramidal neurons after LTP. Journal of Neuroscience, 28 : 8635-8643 - 2008 - Campanac E, Debanne D.
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons. Journal of Physiology (London), 586 : 779-793 - 2007 - Cudmore RH, Goaillard JM, Debanne D.
Inhibition facilitates depression. Journal of Physiology (London), 585 : 323 - 2007 - Boudkkazi S, Carlier E, Ankri N, Caillard O, Giraud P, Fronzaroli-Molinieres L, Debanne D.
Release-dependent variations in synaptic latency: a putative code for short- and long-term synaptic dynamics. Neuron, 56 : 1048-1060 - 2007 - Campanac E, Debanne D.
Plasticity of neuronal excitability: Hebbian rules beyond the synapse. Archives Italiennes de Biologie, 145 : 277-287 - 2006 - Carlier E, Sourdet V, Boudkkazi S, Déglise P, Ankri N, Fronzaroli-Molinieres L, Debanne D.
Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons. Journal of Physiology (London), 577 : 141-154 - 2006 - Debanne D, Gastrein P, Campanac E.
Queer channels in hippocampal basket cells: h-current without sag. Journal of Physiology (London), 574 : 2 - 2006 - Bouzioukh F, Daoudal G, Falk J, Debanne D, Rougon G, Castellani V.
Semaphorin3A regulates synaptic function of differentiated hippocampal neurons. European Journal of Neuroscience, 23 : 2247-2254 - 2004 - Debanne D.
Information processing in the axon. Nature Reviews Neuroscience, 5 : 304-316 - 2003 - Daoudal G, Debanne D.
Long-term plasticity of intrinsic excitability: learning rules and mechanisms. Learning & Memory, 10 : 456-465 - 2003 - Sourdet V, Russier M, Daoudal G, Ankri N, Debanne D.
Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5. Journal of Neuroscience, 23 : 10238-10248 - 2003 - Debanne D, Daoudal G, Sourdet V, Russier M.
Brain plasticity and ion channels. Journal of Physiology (Paris), 97 : 403-414 - 2003 - Garrido JJ, Giraud P, Carlier E, Fernandes F, Moussif A, Fache MP, Debanne D, Dargent B.
A targeting motif involved in sodium channel clustering at the axonal initial segment. Science, 300 : 2091-2094 - 2003 - Russier M, Carlier E, Ankri N, Fronzaroli-Molinieres L, Debanne D.
A-, T-, and H-type currents shape intrinsic firing of developing rat abducens motoneurons. Journal of Physiology (London), 549 : 21-36 - 2003 - Russier M, Debanne D.
Axonal propagation: does the spike stop here? Journal of Physiology (London), 548 : 663 - 2002 - Daoudal G, Hanada Y, Debanne D.
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences USA, 99 : 14512-14517 - 2002 - Russier M, Kopysova I, Ankri N, Ferrand N, Debanne D.
GABA and glycine co-release optimizes functional inhibition in rat brainstem motoneurons in vitro. Journal of Physiology (London), 541 : 123-137
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