The Ion Channel and Synaptic Neurobiology  Laboratory (UNIS UMR_S 1072, director Dominique Debanne) is a joint INSERM and Aix-Marseille University research unit.

The laboratory is comprised of three research groups whose main objectives are to understand the molecular mechanisms of neurotransmission and the role of ion channels in neuronal communication, plasticity and brain diseases. The laboratory also has a technological platform which aims to develop novel molecular tools for the diagnosis and prognosis of autoimmune neurological diseases. We perform assays to detect
autoantibodies against  VGCC as well as VGKC / LGI1

2020 - Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study.

2020 - Structural and molecular modeling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

2019 - The contribution of ion channels in input-output plasticity

2019 - Topological Information Data Analysis

2019 - Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B

2019 - Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons.

2019 - Past and future of analog-digital modulation of synaptic transmission

2019 - Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification

2019 - Plasticity of intrinsic neuronal excitability

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Our laboratory regularly proposes internships and both PhD students and post-doctoral fellows are welcome. Please contact the group ...

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