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YEAR : 1998

Protein interactions implicated in neurotransmitter release.

AUTHORS : El Far O, O'Connor V, Dresbach T, Pellegrini L, DeBello W, Schweizer F, Augustine G, Heuss C, Schäffer T, Charlton MP, Betz H.

JOURNAL : J Physiol Paris
N° Pubmed : 9782456
Biochemical evidence indicates that the exocytotic release of neurotransmitters involves both evolutionary conserved membrane proteins, the SNAREs, as well as ubiquitous cytosolic fusion proteins, NSF and SNAPs. We have analyzed the biochemical properties and the physiological effects of these proteins. Our data suggest models how NSF, SNAPs and SNAREs may function in neurotransmitter exocytosis.