|
PUBLICATIONS
|
HOME PAGE
| PUBLICATIONS
|
|
YEAR : 2025Visual activity enhances neuronal excitability in thalamic relay neuronsAUTHORS : Duménieu M, Fronzaroli-Molinieres L, Naudin L, Iborra C, Wakade A, Zanin E, Aziz A, Ankri N, Incontro S, Denis D, Marqueze B, Brette R, Debanne D, Russier M. JOURNAL : Science Advances Amblyopia, a highly prevalent loss of visual acuity, is classically thought to result from cortical plasticity. The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a passive relay for visual information, but recent findings suggest a largely underestimated functional plasticity in the dLGN. However, the cellular mechanisms supporting this plasticity has not been yet explored. We show here that monocular deprivation (MD), an experimental model of amblyopia, reduces the intrinsic excitability of dLGN cells. Furthermore, dLGN neurons exhibit long-term potentiation of their intrinsic excitability (LTP-IE) when suprathreshold afferent retinal inputs are stimulated at 40 Hz or when spikes are induced with current injection. LTP-IE is observed after eye opening, requires calcium influx, is expressed through the down-regulation of Kv1 channels, and is altered following MD. In conclusion, our study provides the first evidence for intrinsic plasticity in dLGN neurons induced by natural stimuli.
|
|