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YEAR : 2013

Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits

AUTHORS : Campanac E, Gasselin C, Baude A, Rama S, Ankri N, Debanne D.

JOURNAL : Neuron
The dynamics of inhibitory circuits in the cortex is thought to rely mainly on synaptic modifications. We challenge this view by showing that hippocampal parvalbumin-positive basket cells (PV-BCs) of the CA1 region express long-term (>30 min) potentiation of intrinsic neuronal excitability (LTP-IEPV-BC) upon brief repetitive stimulation of the Schaffer collaterals. LTP-IEPV-BC is induced by synaptic activation of metabotropic glutamate receptor subtype 5 (mGluR5) and mediated by the down-regulation of Kv1 channel activity. LTP-IEPV-BC promotes spiking activity at the gamma frequency (~35 Hz) and facilitates recruitment of PV-BCs to balance synaptic and intrinsic excitation in pyramidal neurons. In conclusion, activity-dependent modulation of intrinsic neuronal excitability in PV-BCs maintains excitatory-inhibitory balance and thus plays a major role in the dynamics of hippocampal circuits.