The Ion Channel and Synaptic Neurobiology  Laboratory (UNIS UMR_S 1072, director Dominique Debanne) is a joint INSERM and Aix-Marseille University research unit.

The laboratory is comprised of three research groups whose main objectives are to understand the molecular mechanisms of neurotransmission and the role of ion channels in neuronal communication, plasticity and brain diseases. The laboratory also has a technological platform which aims to develop novel molecular tools for the diagnosis and prognosis of autoimmune neurological diseases. We perform assays to detect
autoantibodies against  VGCC as well as VGKC / LGI1

2021 - Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit

2021 - The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex

2021 - Gene Therapy Strategy for Alzheimer's and Parkinson's Diseases Aimed at Preventing the Formation of Neurotoxic Oligomers in SH-SY5Y Cells

2021 - Mechanisms of plasticity in subcortical visual areas

2021 - A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation

2021 - Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of post-synaptic Kv7 channels

2021 - Therapeutic and Vaccine Strategies for Stopping the COVID-19 Pandemic Based on Structural and Molecular Modeling Studies of Virus-Ganglioside Interactions

2021 - Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

2021 - Formin activity and mDia1 contribute to maintain axon initial segment composition and structure

2021 - Calcium and spike timing-dependent plasticity

2021 - Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease

2021 - Refining the Identity and Role of Kv4 Channels in Mouse Substantia Nigra Dopaminergic Neurons

2021 - Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience

2021 - Structural dynamics of SARS-CoV-2 variants: A health monitoring strategy for anticipating Covid-19 outbreaks

2021 - Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19

2021 - Neural excitability increases with axonal resistance between soma and axon initial segment

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Our laboratory regularly proposes internships and both PhD students and post-doctoral fellows are welcome. Please contact the group ...

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