The Ion Channel and Synaptic Neurobiology  Laboratory (UNIS UMR_S 1072, director Dominique Debanne) is a joint INSERM and Aix-Marseille University research unit.

The laboratory is comprised of three research groups whose main objectives are to understand the molecular mechanisms of neurotransmission and the role of ion channels in neuronal communication, plasticity and brain diseases. The laboratory also has a technological platform which aims to develop novel molecular tools for the diagnosis and prognosis of autoimmune neurological diseases. We perform assays to detect
autoantibodies against  VGCC as well as VGKC / LGI1

2019 - Plasticity of intrinsic neuronal excitability

2018 - Axon initial segment

2018 - The glycosphingolipid MacCer promotes synaptic bouton2 formation in Drosophila by interacting with Wnt

2018 - Pre- and post-synaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis

2018 - Neurotransmitter identity and electrophysiological phenotype are genetically coupled in midbrain dopaminergic neurons

2018 - Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification

2018 - Somatic modulation of ectopic action potential initiation in distal axons

2018 - Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter

2018 - Signal propagation along the axon


Our laboratory regularly proposes internships and both PhD students and post-doctoral fellows are welcome. Please contact the group ...