The Ion Channel and Synaptic Neurobiology  Laboratory (UNIS UMR_S 1072, director Dominique Debanne) is a joint INSERM and Aix-Marseille University research unit.

The laboratory is comprised of two research groups whose main objectives are to understand the molecular mechanisms of neurotransmission and the role of ion channels in neuronal communication, plasticity and brain diseases. The laboratory also has a technological platform which aims to develop novel molecular tools for the diagnosis and prognosis of autoimmune neurological diseases. We perform assays to detect autoantibodies against  VGCC as well as VGKC / LGI1 . 

2023 - Spike timing-dependent plasticity and memory

2023 - AmyP53 Prevents the Formation of Neurotoxic β-Amyloid Oligomers through an Unprecedent Mechanism of Interaction with Gangliosides: Insights for Alzheimer's Disease Therapy.

2023 - Structural basis of botulinum neurotoxin serotype A1 binding to human SV2A or SV2C receptors.

2022 - AmyP53, a Therapeutic Peptide Candidate for the Treatment of Alzheimer's and Parkinson's Disease: Safety, Stability, Pharmacokinetics Parameters and Nose-to Brain Delivery

2022 - Structural Basis of Botulinum Toxin Type F Binding to Glycosylated Human SV2A: In Silico Studies at the Periphery of a Lipid Raft

2022 - Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons

2022 - Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex

2022 - An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel

2022 - Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1

2022 - The epigenetic dimension of protein structure

2022 - Ganglioside binding domains in proteins: Physiological and pathological mechanisms

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Our laboratory regularly proposes internships and both PhD students and post-doctoral fellows are welcome. Please contact the group ...

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