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ANNEE : 2020

Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit

AUTEURS : Diaz-Alonso J, Morishita W, Incontro S, Simms J, Holzman J, Gill M, Mucke L, Malenka RC, Nicoll RA.

REVUE : eLife
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.