PUBLICATIONS

Chercher par auteur :
Tous les AuteursAlcaraz GAmendola JAnkri NAziz AAzzaz FBaudot PBialowas ABoudkkazi SBoumedine NBrechet ACaillard OCampanac ECarlier EChahinian HCoq JOCudmore RHDaoudal GDe San Feliciano MDebanne DDebreux KDenis DDesplantes RDi Giovanni JDubruc FDufour MDuménieu MDéglise PEl Far OExtrémet JFantini JFormisano-Treziny CFronzaroli-Molinieres LFékété AGabert JGasselin CGastrein PGiraud PGoaillard JMHaddjeri-Hopkins AIborra CIncontro SInglebert YLEVEQUE CLopez CLévêque CMarcaggi PMarqueze BMarra VMaulet YMoubarak EMoutot NRama SRamirez-Franco JJRussier MSammari MSangiardi MSeagar MSourdet VTapia MTell FTemporal SUsseglio FWakade AWoodhouse AYahi NYoussouf FZanin EZbili M

Chercher par année de publication :
Toutes les Années2023202220212020201920182017201620152014201320122011201020092008200720062005200420032002200120001999199819971996199519941993199219911990198919881987198619841983198219811980197919781974

Chercher par mot-clé :

	PUBLICATIONS
ACCUEIL   |  PUBLICATIONS

ANNEE : 2019

Robustness to axon initial segment variation is explained by somatodendritic excitability in rat substantia nigra dopaminergic neurons.

AUTEURS : Moubarak E, Engel D, Dufour M, Tapia M, Tell F, Goaillard JM.

REVUE : Journal of Neuroscience
N° Pubmed : 31028116
In many neuronal types, axon initial segment (AIS) geometry critically influences neuronal excitability. Interestingly, the axon of rat substantia nigra pars compacta (SNc) dopaminergic (DA) neurons displays a highly variable location and most often arises from an axon-bearing dendrite (ABD). We combined current-clamp somatic and dendritic recordings, outside-out recordings of dendritic sodium and potassium currents, morphological reconstructions and multi-compartment modelling on male and female rat SNc DA neurons to determine cell-to-cell variations in AIS and ABD geometry and their influence on neuronal output (spontaneous pacemaking frequency, AP shape). Both AIS and ABD geometries were found to be highly variable from neuron to neuron. Surprisingly, we found that AP shape and pacemaking frequency were independent of AIS geometry. Modelling realistic morphological and biophysical variations helped us clarify this result: in SNc DA neurons, the complexity of the ABD combined with its excitability predominantly define pacemaking frequency and AP shape, such that large variations in AIS geometry negligibly affect neuronal output, and are tolerated.