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PUBLICATIONS :- 2024 - Ramirez-Franco JJ, Debreux K, Sangiardi M, Belghazi M, Kim Y, Lee SH, Lévêque C, Seagar M, El Far O.
The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels
Neurobiology of Disease, 196 : 106513 - 2022 - Ramirez-Franco JJ, Debreux K, Extrémet J, Maulet Y, Belghazi M, Villard C, Sangiardi M, Youssouf F, El Far L, Lévêque C, Debarnot C, Marchot P, , Debanne D, Russier M, Seagar M, Irani S, El Far O.
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Brain, doi: 10.1093/brain/awac218 - 2022 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci G, Youssouf F, Popooff MR, Seagar M, Lévêque C, Fantini JEl Far O.
Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
Cell Mol Life Sci, 79 : 496 - 2021 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci Géraldine, Youssouf F, Popoff Michel Robert, Seagar M, Lévêque C, Fantini JEl Far O.
The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex
BioRxiv - 2019 - Rama S, Boumedine N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne DEl Far O.
Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification
Molecular Neurobiology, 56 : 3591-3602 - 2019 - Flores A, Ramirez-Franco JJ, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf FSangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque CEl Far O.
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1908051116 - 2017 - Desplantes R, Lévêque C, Muller B, Loterzio M, Ferracci G, Popoff M, Seagar M, Mamoun R, El Far O.
Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor
Scientific Reports, 7 : 1032 - 2017 - Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine N, Rodriguez L, Zbili MUsseglio F, Formisano-Treziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne DEl Far O.
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
Proceedings of the National Academy of Sciences USA, 114 : 7719-7724 - 2015 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Seagar M, El Far O.
A chip-based assay for botulinum neurotoxin A activity in pharmaceutical preparations.
Appl Microbiol Biotechnol. , 99 : 4355-4360 - 2015 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff MR, Blanchard MP, Seagar M, El Far O.
An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E
Scientific Reports, 5 : 17953 - 2015 - Hammond C, El Far O, Seagar M.
Neurotransmitter release
Cellular and molecular neurophysiology - 2015 - El Far O, Seagar M.
The synaptic vesicle V-ATPase: a regulatory link between loading and fusion?
Presynaptic terminals - 2015 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff MR, Blanchard MP, Seagar M, El Far O.
An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E.
Scientific Reports, 5:17953 - 2014 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff M, Seagar M, El Far O.
Direct biosensor detection of botulinum neurotoxin endopeptidase activity in sera from patients with type A botulism
Biosensors and Bioelectronics, 57 : 207-212 - 2014 - Mlayah-Bellalouna S, Dufour M, Mabrouk S, Mejdoub, H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.
AaTX1, from Androctonus australis scorpion venom: Purification, synthesis and characterization in dopaminergic neurons
Toxicon, 92 : 14-23 - 2013 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Blanchard MP, Seagar M, El Far O.
A substrate sensor chip to assay the enzymatic activity of Botulinum neurotoxin A.
Biosensors & Bioelectronics, 49 : 276-281 - 2011 - El Far O, Seagar M.
A role for V-ATPase subunits in synaptic vesicle fusion?
Journal of Neurochemistry, 117 : 603-612 - 2011 - El Far O, Seagar M.
SNARE, V-ATPase and neurotransmission
Med Sci (Paris), 27 : 28-31 - 2011 - Ferracci G, Marconi S, Mazuet C, Jover E, Blanchard MP, Seagar M, Popoff M, Lévêque C.
A label-free biosensor assay for botulinum neurotoxin B in food and human serum.
Anal Biochem, 410 : 281-288 - 2010 - Di Giovanni J, Boudkkazi S, Mochida S, Bialowas A, Samari N, Lévêque C, Youssouf F, Brechet A, Iborra CMaulet Y, Moutot N, Debanne D, Seagar M, El Far O.
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release.
Neuron, 67 : 268-279 - 2010 - Di Giovanni J, Iborra C, Maulet Y, Lévêque C, El Far O, Seagar M.
Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin
J Biol Chem, 285 : 23665-23675 - 2010 - Karatekin E, Di Giovanni J, Iborra C, Coleman J, O'Shaughnessy B, Seagar M, Rothman JE.
A fast, single-vesicle fusion assay mimics physiological SNARE requirements.
Proc Natl Acad Sci USA, 107 : 3517-3521 - 2008 - Marconi S, Ferracci G, Berthomieu M, Kozaki S, Miquelis R, Boucraut J, Seagar M, Lévêque C.
A protein chip membrane-capture assay for botulinum neurotoxin activity.
Toxicol Appl Pharmacol, 233 : 439-446 - 2008 - Moutot N, De Haro L, Seagar M.
Distinct evolution of calcium channel antibody types in Lambert-Eaton myasthenic syndrome.
J Neuroimmunol, 197 : 47-53 - 2008 - Marqueze B, Moutot N, Sakkou-Norton M, Lévêque C, Ji Y, Cornet V, Hsiao WL, Seagar M.
Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.
Traffic, 9 : 1088-1100 - 2007 - Ji Y, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Lévêque C, Queen L, Reebye V, Pal P, Gkaliagkousi E, Seagar M, Ferro A.
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90.
Proc Natl Acad Sci U S A, 104 : 8839-8844 - 2006 - Lacoste C, Barthaux V, Iborra C, Seagar M, Erard-Garcia M.
MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans.
Dev Biol, 294 : 181-191 - 2006 - Moutot N, Mansuelle P, Alcaraz G, Dos Santos RG, Cordeiro MN, De Lima ME, Seagar M, Van Renterghem C.
Phoneutria nigriventer toxin 1: a novel, state-dependent inhibitor of neuronal sodium channels that interacts with micro conotoxin binding sites.
Mol Pharmacol, 69 : 1931-1937 - 2006 - Moutot N, De Haro L, Santos RG, Mori Y, Seagar M.
Phoneutria nigriventer omega-Phonetoxin IIA: a new tool for anti-calcium channel autoantibody assays in Lambert-Eaton myasthenic syndrome.
Neurobiol Dis, 22 : 57-63 - 2005 - Ferracci G, Miquelis R, Kozaki S, Seagar M, Lévêque C.
Synaptic vesicle chips to assay botulinum neurotoxins.
Biochem J, 391 : 659-66 - 2004 - Ferracci G, Seagar M, Joël C, Miquelis R, Lévêque C.
Real time analysis of intact organelles using surface plasmon resonance.
Anal Biochem, 334 : 367-375 - 2004 - Moutot N, De Haro L, Seagar M.
[Dosage and specificity of anti-calcium channel antibodies in Lambert-Eaton myasthenic syndrome].
Rev Neurol (Paris), 165 : S28-S34 - 2004 - De Haro L, Ferracci G, Opi S, Iborra C, Quetglas S, Miquelis R, Lévêque C, Seagar M.
Ca2+/calmodulin transfers the membrane-proximal lipid-binding domain of the v-SNARE synaptobrevin from cis to trans bilayers.
Proc Natl Acad Sci U S A, 101 : 1578-1583 - 2003 - De Haro L, Quetglas S, Iborra C, Lévêque C, Seagar M.
Calmodulin-dependent regulation of a lipid binding domain in the v-SNARE synaptobrevin and its role in vesicular fusion.
Biol Cell, 95 : 459-464 - 2002 - Quetglas S, Iborra C, Sasakawa N, De Haro l, Kumakura K, Sato K, Lévêque C, Seagar M.
Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.
EMBO J, 21 : 3970-3979 - 2002 - Dos Santos RG, Van Renterghem C, Moutot N, Mansuelle P, Cordeiro MN, Diniz CR, Mori Y, De Lima ME, Seagar M
Phoneutria nigriventer omega-phonetoxin IIA blocks the Cav2 family of calcium channels and interacts with omega-conotoxin-binding sites.
J Biol Chem, 277 : 13856-13862 - 2001 - Ashton AC, Volynski KE, Lelianova VG, Orlova EV, Van Renterghem C, Canepari M, Seagar M, Ushkaryov YA.
alpha-Latrotoxin, acting via two Ca2+-dependent pathways, triggers exocytosis of two pools of synaptic vesicles.
J Biol Chem, 276 : 44695-44703 - 2001 - Minami K, Raymond C, Moutot N, Ohtake A, Van Renterghem C, Takahashi M, Seagar MMori Y, Sato K.
Role of Thr(11) in the binding of omega-conotoxin MVIIC to N-type Ca2+ channels.
FEBS Lett, 491 : 127-130 - 2001 - Seagar M, Quetglas S, Iborra C, Lévêque C.
Le complexe SNARE au coeur de la fusion membranaire
Med. Sci, 5 : 669-674 - 2000 - Couraud F, Seagar M.
[Calcium channels and migraine].
Pathol Biol (Paris), 48 : 642-647 - 2000 - Van Renterghem C, Iborra C, Moutot N, Lelianova V, Ushkaryov Y, Seagar M.
alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin.
Eur J Neurosci, 12 : 3953-3962 - 2000 - Quetglas S, Lévêque C, Miquelis R, Sato K, Seagar M.
Ca2+-dependent regulation of synaptic SNARE complex assembly via a calmodulin- and phospholipid-binding domain of synaptobrevin.
Proc Natl Acad Sci U S A, 97 : 9695-9700 - 2000 - Hermitte L, Moutot N, Boucraut J, Barone R, Atlan-Gepner C, Seagar M, Pouget J, Kleisbauer JP, Couraud F.
Humoral immunity against glutamic acid decarboxylase and tyrosine phosphatase IA-2 in Lambert-Eaton myasthenic syndrome.
J Clin Immunol, 20 : 287-293 - 2000 - Marqueze B, Berton F, Seagar M.
Synaptotagmins in membrane traffic: which vesicles do the tagmins tag?
Biochimie, 82 : 409-420 - 2000 - Berton F, Cornet V, Iborra C, Garrido J, Dargent B, Fukuda M, Seagar M, Marqueze B.
Synaptotagmin I and IV define distinct populations of neuronal transport vesicles.
Eur J Neurosci, 12 : 1294-1302 - 2000 - Sampo B, Tricaud N, Lévêque C, Seagar M, Couraud F, Dargent B.
Direct interaction between synaptotagmin and the intracellular loop I-II of neuronal voltage-sensitive sodium channels.
Proc Natl Acad Sci U S A, 97 : 3666-3671 - 2000 - Sato K, Raymond C, Moutot N, Sasaki T, Ohtake A, Minami K, Van Renterghem C, Kim JI, Takahashi M, Seagar M.
Binding of Ala-scanning analogs of omega-conotoxin MVIIC to N- and P/Q-type calcium channels.
FEBS Lett, 469 : 147-159 - 2000 - Sato K, Raymond C, Moutot NSasaki T, Ohtake A, Minami K, Van Renterghem C, Takahashi M, Seagar M.
Binding of six chimeric analogs of omega-conotoxin MVIIA and MVIIC to N- and P/Q-type calcium channels.
Biochem Biophys Res Commun, 269 : 254-256 - 2000 - Lévêque C, Boudier JA, Takahashi M, Seagar M.
Calcium-dependent dissociation of synaptotagmin from synaptic SNARE complexes.
J Neurochem, 74 : 367-374 - 1999 - Boudier JA, Moutot N, Boudier JL, Iborra C, Takahashi M, Seagar M.
Redistribution of presynaptic proteins during alpha-latrotoxin-induced release of neurotransmitter and membrane retrieval at the frog neuromuscular junction.
Eur J Neurosci, 11 : 3449-3456 - 1999 - Seagar M, Lévêque C, Charvin N, Marqueze B, Moutot N, Boudier JA, Boudier JL, Shoji-Kasai Y, Sato K.
Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.
Philos Trans R Soc Lond B Biol Sci, 354 : 289-297 - 1999 - Raymond C, Walker D, Bichet D, Iborra C, Moutot N, Seagar M, De Waard M.
Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome.
Neuroscience, 90 : 269-277 - 1998 - Seagar M, Takahashi M.
Interactions between presynaptic calcium channels and proteins implicated in synaptic vesicle trafficking and exocytosis.
J Bioenerg Biomembr, 30 : 347-356 - 1998 - Lévêque C, Pupier S, Marqueze B, Geslin L, Kataoka M, Takahashi M, De Waard M, Seagar M.
Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel.
J Biol Chem, 273 : 13488-13492 - 1998 - Seagar M, Lévêque C, Charvin N, Marqueze B, Moutot N, Boudier JA, Boudier JL, Kataoka M, Shoji-Kaisai Y, Takahashi M.
Interactions between proteins implicated in exocytosis and voltage-gated calcium channels.
Eur J Neurosci, 10 : 12501 - 1998 - Seagar M, Moutot N, Raymond C, Charvin N, Lévêque C, Walker D, De Waard M.
Omega-conotoxins : diagnostic tools for an autoimmune disease of the neuromuscular juction
Toxicon, 36 : 1730-1731 - 1997 - Sato K, Raymond C, Moutot N, Sasaki T, Omori A, Ohtaki A, Kim JI, Kohno T, Takahashi M, Seagar M.
Binding of chimeric analogs of omega-conotoxin MVIIA and MVIIC to the N- and P/Q-type calcium channels.
FEBS Lett, 414 : 480-484 - 1997 - Charvin N, Lévêque C, Walker D, Berton F, Raymond C, Kataoka M, Shoji-Kasai Y, Takahashi M, De Waard M, Seagar M.
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.
EMO J, 16 : 4591-4596 - 1997 - Pupier S, Lévêque C, Marqueze B, Kataoka M, Takahashi M, Seagar M.
Cysteine string proteins associated with secretory granules of the rat neurohypophysis.
J Neurosci, 17 : 2722-2727 - 1997 - Berton F, Iborra C, Boudier JA, Seagar M, Marqueze B.
Developmental regulation of synaptotagmin I, II, III, and IV mRNAs in the rat CNS.
J Neurosci, 17 : 1206-1216 - 1996 - Arsac C, Raymond C, Moutot N, Dargent B, Couraud F, Poget J, Seagar M.
Immunoassays fail to detect antibodies against neuronal calcium channels in amyotrophic lateral sclerosis serum.
Ann Neurol, 40 : 695-700 - 1996 - Moutot N, Charvin N, Lévêque C, Sato K, Nishiki T, Kozaki S, Takahashi M, Seagar M.
Interaction of SNARE complexes with P/Q-type calcium channels in rat cerebellar synaptosomes.
J Biol Chem, 271 : 6567-6570 - 1996 - Boudier JA, Charvin N, Boudier JL, Fathallah M, Tagaya M, Takahashi M, Seagar M.
Distribution of components of the SNARE complex in relation to transmitter release sites at the frog neuromuscular junction.
Eur J Neurosci, 8 : 545-552 - 1995 - El Far O, Marqueze B, Lévêque C, Moutot N, Lang B, Newsom-Davis J, Yoshida A, Takahashi M, Seagar M
Antigens associated with N- and L-type calcium channels in Lambert-Eaton myasthenic syndrome.
J Neurochem, 64 : 1696-1702 - 1995 - El Far O, Charvin N, Lévêque C, Moutot N, Takahashi M, Seagar M.
Interaction of a synaptobrevin (VAMP)-syntaxin complex with presynaptic calcium channels.
FEBS Lett, 361 : 101-105 - 1995 - Kim JI, Takaashi M, Moutot N, Seagar M, Ohtake A, Sato K.
Tyr13 is essential for the binding of omega-conotoxin MVIIC to the P/Q-type calcium channel.
Biochem Biophys Res Commun, 214 : 305-309 - 1995 - Marqueze B, Boudier JA, Mizuta M, Inagaki M, Seino S, Seagar M.
Cellular localization of synaptotagmin I, II, and III mRNAs in the central nervous system and pituitary and adrenal glands of the rat.
J Neurosci, 15 : 4906-4917 - 1995 - Moutot N, Lévêque C, Sato K, Kato R, Takahashi M, Seagar M.
Properties of omega conotoxin MVIIC receptors associated with alpha 1A calcium channel subunits in rat brain.
FEBS Lett, 366 : 21-25 - 1995 - Angaut-Petit D, Juzans P, Molgo J, Faille L, Seagar M, Takahashi M, Shoji-Kasai Y.
Mouse motor nerve terminal immunoreactivity to synaptotagmin II during sustained quantal transmitter release.
Brain Res, 68 : 213-217 - 1995 - Moutot N, Lang B, Newsom-Davis J, Seagar M.
Binding of Lambert-Eaton myasthenic syndrome IgG to synaptosomal proteins does not correlate with an inhibition of calcium uptake.
Neurosci Lett, 187 : 11(-118 - 1995 - Seagar M, Moutot N, Lévêque C, Marqueze B, Pouget J.
Anti-calcium channel autoantibodies in amyotrophic lateral sclerosis. A review of the evidence.
Adv Neurol, 68 : 67-72 - 1994 - Lévêque C, El Far O, Moutot N, Sato K, Kato R, Takahashi M, Seagar M.
Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.
J Biol Chem, 269 : 6306-6312 - 1993 - El Far O, Moutot N, Lévêque C, David P, Marqueze B, Lang B, Newom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin associates with presynaptic calcium channels and is a Lambert-Eaton myasthenic syndrome antigen.
Ann N Y Acad Sci, 707 : 382-385 - 1993 - David P, Moutot N, Lévêque C, El Far O, Takahashi M, Seagar M.
Interaction of synaptotagmin with voltage gated calcium channels: a role in Lambert-Eaton myasthenic syndrome?
Neuromuscul Disord, 3 : 451-454 - 1993 - David P, El Far O, Moutot N, Poupon MF, Takahashi M, Seagar M.
Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.
FEBS Lett, 326 : 135-139 - 1993 - Seagar M, Moutot N, Lévêque C, El Far O, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M.
A Lambert-Eaton myasthenic syndrome antigen associated with presynaptic calcium channels.
Biochem Soc Trans, 21 : 423-428 - 1993 - Moutot N, El Far O, Lévêque C, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin: a Lambert-Eaton myasthenic syndrome antigen that associates with presynaptic calcium channels.
J Physiol Paris, 87 : 37-41 - 1993 - McEnery MW, Snowman AM, Seagar M, Copeland TD, Takahashi M.
Immunological characterization of proteins associated with the purified omega-conotoxin GVIA receptor.
Ann N Y Acad Sci, 707 : 386-391 - 1993 - Lang B, Johnston I, Leys K, Elrington G, Marqueze B, Lévêque C, Moutot N, Seagar M, Hoshino T, Takahashi M, Sugimori M, Cherksey BD, Llinas R.
Autoantibody specificities in Lambert-Eaton myasthenic syndrome.
Ann N Y Acad Sci, 681 : 382-393 - 1993 - Grignon S, Seagar M, Couraud F.
Omega-conotoxin sensitive calcium channels in cerebellar granule cells are not coupled to [3H]glutamate release.
Neurosci Lett, 155 : 8è-91 - 1992 - Lévêque C, Hoshino T, David P, Shoji-Kasai Y, Leys K, Omori A, Lang B , El Far O, Sato K, Newsom-Davis J, Takahashi M, Moutot N, Seagar M.
The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen.
Proc Natl Acad Sci U S A, 89 : 3625-3629 - 1992 - De Waard M, Seagar M, Feltz A, Couraud F.
Inositol phosphate regulation of voltage-dependent calcium channels in cerebellar granule neurons.
Neuron, 9 : 497-503 - 1990 - Lai Y, Seagar M, Takahashi M, Catterall WA.
Cyclic AMP-dependent phosphorylation of two size forms of alpha 1 subunits of L-type calcium channels in rat skeletal muscle cells.
J Biol Chem, 265 : 20839-20948 - 1990 - Lévêque C, Marqueze B, Couraud F, Seagar M.
Polypeptide components of the apamin receptor associated with a calcium activated potassium channel.
FEBS Lett, 275 : 185-189 - 1990 - Moutot N, Seagar M, Couraud F.
Subtypes of voltage-sensitive calcium channels in cultured rat brain neurons.
Neurosci Lett, 115 : 300-306 - 1987 - Seagar M, Deprez P, Moutot N, Couraud.
Detection and photoaffinity labeling of the Ca2+-activated K+ channel-associated apamin receptor in cultured astrocytes from rat brain.
Brain Res, 411 : 226-230
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