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Site web : http://cvscience.aviesan.fr/cv/538/oussama-el-far
PUBLICATIONS :- 2024 - Ramirez-Franco JJ, Debreux K, Sangiardi M, Belghazi M, Kim Y, Lee SH, Lévêque C, Seagar M, El Far O.
The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels
Neurobiology of Disease, 196 : 106513 - 2023 - Extrémet J, Ramirez-Franco JJ, Fronzaroli-Molinieres L, Boumedine N, Ankri N, El Far O, Garrido JJ, Debanne D, Russier M
Rescue of normal excitability in LGI1-deficient epileptic neurons
Journal of Neuroscience, 43 : 8596-8606 - 2022 - Ramirez-Franco JJ, Debreux K, Extrémet J, Maulet Y, Belghazi M, Villard C, Sangiardi M, Youssouf F, El Far L, Lévêque C, Debarnot C, Marchot P, , Debanne D, Russier M, Seagar M, Irani S, El Far O.
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Brain, doi: 10.1093/brain/awac218 - 2022 - Extrémet J, El Far O, Ankri N, Irani SR, Debanne D, Russier M.
An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel
Cells, 11 : 2713 - 2022 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci G, Youssouf F, Popooff MR, Seagar M, Lévêque C, Fantini JEl Far O.
Molecular landscape of BoNT/B bound to a membrane-inserted synaptotagmin/ganglioside complex
Cell Mol Life Sci, 79 : 496 - 2021 - Ramirez-Franco JJ, Azzaz F, Sangiardi M, Ferracci Géraldine, Youssouf F, Popoff Michel Robert, Seagar M, Lévêque C, Fantini JEl Far O.
The protein-binding pocket of Botulinum neurotoxin B accommodates a preassembled synaptotagmin / ganglioside complex
BioRxiv - 2020 - Ramberger M, Berretta A,Tan JMM, Sun B, Michael S, Yeo T, Theorell J, Bashford-Rogers R, Paneva S, O'Dowd V, Dedi N,, Topia S, Griffin R, Ramirez-Franco JJ, El Far O, Baulac S, Leite M, Sen A, Jeans A, McMillan D, Marshall D, Antony D, Lightwood D, Waters P, Irani SR.
Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Brain, 143 : 1731-1745 - 2019 - Rama S, Boumedine N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne DEl Far O.
Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification
Molecular Neurobiology, 56 : 3591-3602 - 2019 - Flores A, Ramirez-Franco JJ, Desplantes R, Debreux K, Ferracci G, Wernert F, Blanchard MP, Maulet Y, Youssouf FSangiardi M, Iborra C, Popoff MR, Seagar M, Fantini J, Lévêque CEl Far O.
Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B
PNAS, www.pnas.org/cgi/doi/10.1073/pnas.1908051116 - 2018 - Debanne D, El Far O.
Pre- and post-synaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis
Brain, 141 : 3092-3095 - 2017 - Desplantes R, Lévêque C, Muller B, Loterzio M, Ferracci G, Popoff M, Seagar M, Mamoun R, El Far O.
Affinity biosensors using recombinant native membrane proteins displayed on exosomes: application to botulinum neurotoxin B receptor
Scientific Reports, 7 : 1032 - 2017 - Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine N, Rodriguez L, Zbili MUsseglio F, Formisano-Treziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne DEl Far O.
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels
Proceedings of the National Academy of Sciences USA, 114 : 7719-7724 - 2015 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Seagar M, El Far O.
A chip-based assay for botulinum neurotoxin A activity in pharmaceutical preparations.
Appl Microbiol Biotechnol. , 99 : 4355-4360 - 2015 - Amendola J, Boumedine N, Sangiardi M, El Far O.
Optimization of neuronal cultures from rat superior cervical ganglia for dual patch recording
Scientific Reports, 5 : 14455 - 2015 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff MR, Blanchard MP, Seagar M, El Far O.
An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E
Scientific Reports, 5 : 17953 - 2015 - Hammond C, El Far O, Seagar M.
Neurotransmitter release
Cellular and molecular neurophysiology - 2015 - El Far O, Seagar M.
The synaptic vesicle V-ATPase: a regulatory link between loading and fusion?
Presynaptic terminals - 2015 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff MR, Blanchard MP, Seagar M, El Far O.
An optical biosensor assay for rapid dual detection of Botulinum neurotoxins A and E.
Scientific Reports, 5:17953 - 2014 - Lévêque C, Ferracci G, Maulet Y, Mazuet C, Popoff M, Seagar M, El Far O.
Direct biosensor detection of botulinum neurotoxin endopeptidase activity in sera from patients with type A botulism
Biosensors and Bioelectronics, 57 : 207-212 - 2013 - Lévêque C, Ferracci G, Maulet Y, Grand-Masson C, Blanchard MP, Seagar M, El Far O.
A substrate sensor chip to assay the enzymatic activity of Botulinum neurotoxin A.
Biosensors & Bioelectronics, 49 : 276-281 - 2011 - El Far O, Seagar M.
A role for V-ATPase subunits in synaptic vesicle fusion?
Journal of Neurochemistry, 117 : 603-612 - 2011 - El Far O, Seagar M.
SNARE, V-ATPase and neurotransmission
Med Sci (Paris), 27 : 28-31 - 2010 - Di Giovanni J, Boudkkazi S, Mochida S, Bialowas A, Samari N, Lévêque C, Youssouf F, Brechet A, Iborra CMaulet Y, Moutot N, Debanne D, Seagar M, El Far O.
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release.
Neuron, 67 : 268-279 - 2010 - Di Giovanni J, Iborra C, Maulet Y, Lévêque C, El Far O, Seagar M.
Calcium-dependent regulation of SNARE-mediated membrane fusion by calmodulin
J Biol Chem, 285 : 23665-23675 - 2008 - SCHESCHONKA A, FINDLOW S, SCHEMM R, El Far O, CALDWELL JH, CRUMP MP, HOLDEN-DYE K, O'CONNOR V, BETZ H.
Structural determinants of calmodulin binding to the intracellular C-terminal domain of the metabotropic glutamate receptor 7A
J Biol Chem, 283 : 5577-5588 - 2006 - BERTASO F, LILL Y, AIRAS J, ESPEUT J, BLAHOS J, BOCKAERT J, FAGNI L, BETZ H, El Far O
MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels.
J Neurochem, 99 : 288-298 - 2006 - PARNAS I, RASHKOVAN G, O'CONNOR V, El Far O, BETZ H, PARNAS H.
Role of NSF in neurotransmitter release: a peptide microinjection study at the crayfish neuromuscular junction.
J NEUROPHYSIOL, 96 : 1053-1060 - 2005 - TANG Z, El Far O, BETZ H, SCHESCHONKA A.
Pias1 interaction and sumoylation of metabotropic glutamate receptor 8.
J Biol Chem, 280 : 53-59 - 2004 - OHNO K, KOROLL M, El Far O, SCHOLZE P, GOMEZA J, BETZ H.
The neuronal glycine transporter 2 interacts with the PDZ domain protein syntenin-1.
Mol Cell Neurosci, 26 : 518-529 - 2002 - Horikawa HP, Kneussel M, El Far O, Betz H.
Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin.
Mol Cell Neurosci, 21 : 454-462 - 2002 - Fuhrmann JC, Kins S, Rostaing P, El Far O, Kirsch J, Sheng M, Triller A, Betz H, Kneussel M.
Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes.
J Neurosci, 22 : 5393-5402 - 2002 - Perroy J, El Far O, Bertaso F, Pin JP, Betz H, Bockaert J, Fagni L.
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.
EMBO J, 21 : 2990-2999 - 2002 - Jess U, El Far O, Kirsch J, Betz H.
Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C.
Biochem Biophys Tes Commun, 294 : 272-279 - 2002 - El Far O, Betz H.
G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes.
Biochem J, 365 : 329-336 - 2002 - El Far O, Betz H.
Synaptophysins: vesicular cation channels?
J Physiol, 539 : 332 - 2001 - El Far O, Bofill-Cardona E, Airas JM, O'Connor V, Boehm S, Freissmuth M, Nanoff C, Betz H.
Mapping of calmodulin and Gbetagamma binding domains within the C-terminal region of the metabotropic glutamate receptor 7A.
J Biol Chem, 276 : 30662-30669 - 2001 - Airas JM, Betz H, El Far O.
PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding.
FEBS Lett, 494 : 60-63 - 2000 - El Far O, Airas J, Wischmeyer E, Nehring R, Karschin A, Betz H.
Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1.
Eur J Neurosci, 12 : 4215-4221 - 2000 - Horiuchi M, El Far O, Betz H.
Ulip6, a novel unc-33 and dihydropyrimidinase related protein highly expressed in developing rat brain.
FEBS Lett, 480 : 283-286 - 2000 - Nehring RB, Horikawa HP, El Far O, Kneussel M, Brandstätter JH, Stamm S, Wischmeyer E, Betz H, Karschin A.
The metabotropic GABAB receptor directly interacts with the activating transcription factor 4.
J Biol Chem, 275 : 35185-35191 - 1999 - O'Connor V, El Far O, Bofill-Cardona E, Nanoff C, Freissmuth M, Karschin A, Airas JM, Betz H, Boehm S.
Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.
Science, 286 : 1180-1184 - 1998 - El Far O, O'Connor V, Dresbach T, Pellegrini L, DeBello W, Schweizer F, Augustine G, Heuss C, Schäffer T, Charlton MP, Betz H.
Protein interactions implicated in neurotransmitter release.
J Physiol Paris, 92 : 129-133 - 1998 - Morgan CW, El Far O, Berntson A, Wässle H, Taylor WR.
Calcium extrusion from mammalian photoreceptor terminals.
J Neurosci, 18 : 2467-2474 - 1996 - O'Connor V, Pellegrini L, Dresbach T, Bommert K, El Far O, Betz H, DeBello W, Hunt JM, Schweizer F, Augustine G, Charlton MP.
Protein-protein interactions in synaptic vesicle exocytosis.
Biochem Soc Trans, 24 : 666-670 - 1995 - El Far O, Marqueze B, Lévêque C, Moutot N, Lang B, Newsom-Davis J, Yoshida A, Takahashi M, Seagar M
Antigens associated with N- and L-type calcium channels in Lambert-Eaton myasthenic syndrome.
J Neurochem, 64 : 1696-1702 - 1995 - El Far O, Charvin N, Lévêque C, Moutot N, Takahashi M, Seagar M.
Interaction of a synaptobrevin (VAMP)-syntaxin complex with presynaptic calcium channels.
FEBS Lett, 361 : 101-105 - 1994 - Lévêque C, El Far O, Moutot N, Sato K, Kato R, Takahashi M, Seagar M.
Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.
J Biol Chem, 269 : 6306-6312 - 1993 - El Far O, Moutot N, Lévêque C, David P, Marqueze B, Lang B, Newom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin associates with presynaptic calcium channels and is a Lambert-Eaton myasthenic syndrome antigen.
Ann N Y Acad Sci, 707 : 382-385 - 1993 - David P, Moutot N, Lévêque C, El Far O, Takahashi M, Seagar M.
Interaction of synaptotagmin with voltage gated calcium channels: a role in Lambert-Eaton myasthenic syndrome?
Neuromuscul Disord, 3 : 451-454 - 1993 - David P, El Far O, Moutot N, Poupon MF, Takahashi M, Seagar M.
Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.
FEBS Lett, 326 : 135-139 - 1993 - Seagar M, Moutot N, Lévêque C, El Far O, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M.
A Lambert-Eaton myasthenic syndrome antigen associated with presynaptic calcium channels.
Biochem Soc Trans, 21 : 423-428 - 1993 - Moutot N, El Far O, Lévêque C, David P, Marqueze B, Lang B, Newsom-Davis J, Hoshino T, Takahashi M, Seagar M.
Synaptotagmin: a Lambert-Eaton myasthenic syndrome antigen that associates with presynaptic calcium channels.
J Physiol Paris, 87 : 37-41 - 1992 - Lévêque C, Hoshino T, David P, Shoji-Kasai Y, Leys K, Omori A, Lang B , El Far O, Sato K, Newsom-Davis J, Takahashi M, Moutot N, Seagar M.
The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen.
Proc Natl Acad Sci U S A, 89 : 3625-3629
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