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Principales contributions scientifiques: -Spike-timing dependent plasticity (STDP; Debanne et al., PNAS 1994; Debanne et al., PNAS 1996; Debanne et al., J Neurophysiol 1997; Debanne et al., J Physiol 1998; Debanne et al., J Neurosci 1999; Campanac & Debanne, J Physiol 2008; Inglebert et al., PNAS 2020; Inglebert & Debanne, Front Cell Neurosci 2021; Debanne & Inglebert, Curr Opin Neurobiol 2023) -Plasticité de l'excitabilité neuronale intrinsèque (Daoudal et al., PNAS 2002; Sourdet et al., J Neurosci 2003; Campanac & Debanne, J Physiol 2008; Campanac et al., J Neurosci. 2008; Cudmore et al., J Neurosci 2010; Campanac et al., Neuron 2013; Gasselin et al., J Physiol 2015; Gasselin et al., Sci Rep 2017; Debanne et al. Curr Opin Neurobiol 2019; Incontro et al., J Neurosci 2021; Sammari et al., PNAS 2022) -Physiologie axonale (Debanne et al., Nature 1997; Kopysova & Debanne, J Neurosci 1998; Bialowas et al., EJN 2015; Rama et al., Nat Commun 2015; Rama et al., Sci Rep 2017; Rama et al., Curr Opin Neurobiol 2018; Zbili et al. Sci Adv 2020; Fékété et al., PNAS 2021; Zbili et al., PNAS 2021) -Déterminants du temps neuronal : fidélité de la décharge (Sourdet et al., J Neurosci 2003; Cudmore et al., J Neurosci 2010; Gastrein et al., J Physiol 2011) et délai synaptique (Boudkkazi et al., Neuron 2007; Boudkkazi et al.,J Physiol 2011) -Epilepsie (McKinney et al., Nat Med 1997; Debanne et al., Epilepsia 2006; Seagar et al., PNAS 2017; Debanne & El Far, Brain 2018; Ramirez-Franco et al., Brain 2022; Extrémet et al., Cells 2022) -Développement des propriétés synaptiques et intrinsèques des motoneurones abducens (Russier et al., J Physiol 2002; Russier et al., J Physiol 2003)-Plasticité visuelle corticale (Debanne et al., J Physiol 1998) Principaux contrats de recherche: -AVENIR INSERM 2000 -ACI Jeunes Chercheurs 2000 -FP6 - EC 2004 Synscaff -ANR NMP 2006 Excion -ANR NMP 2008 Episom -APO Région PACA 2009 -ANR Blanc Neurosciences 2011 Reprek -ANR Blanc Biologie cellulaire 2011 Moment -FRM Physiopathologie du système visuel 2013-2017 -ANR Neurosciences 2014-2018 Axode -NSF-ANR Computational Neuroscience 2014-2018 Syncity -ANR Neurosciences 2017-2022 LoGIK -FRM Equipe 2018 (2019-2023) -ANR Neurosciences 2021-2025 Plastinex -Région SUD 2021-2024 Désomlibex -A*Midex Equipement 2023-2025 AOD4AOP -A*Midex Recherche 2024-2026 SOMLIBIN -ANR Neuroscience 2023-2027 SYNCHROSYN
PUBLICATIONS :- 2023 - Debanne D, Inglebert Y.
Spike timing-dependent plasticity and memory Current Opinion in Neurobiology, 80 : 102707 - 2023 - Ankri N, Debanne D.
A fast Markovian method for modeling channel noise in neurons Helyion, 9 : e16953 - 2023 - Duménieu M, Fronzaroli-Molinieres L, Iborra C, Wakade A, Zanin E, Aziz A, Ankri N, Incontro S, Denis DBrette R, Marqueze B, Debanne D, Russier M.
Visual activity enhances neuronal excitability in thalamic relay neurons BioRxiv - 2023 - Extrémet J, Ramirez-Franco JJ, Fronzaroli-Molinieres L, Boumedine N, Ankri N, El Far O, Garrido JJ, Debanne D, Russier M
Rescue of normal excitability in LGI1-deficient epileptic neurons BioRxiv - 2022 - Ramirez-Franco JJ, Debreux K, Extrémet J, Maulet Y, Belghazi M, Villard C, Sangiardi M, Youssouf F, El Far L, Lévêque C, Debarnot C, Marchot P, , Debanne D, Russier M, Seagar M, Irani S, El Far O.
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1 Brain, doi: 10.1093/brain/awac218 - 2022 - Extrémet J, El Far O, Ankri N, Irani SR, Debanne D, Russier M.
An Epitope-Specific LGI1-Autoantibody Enhances Neuronal Excitability by Modulating Kv1.1 Channel Cells, 11 : 2713 - 2022 - Sammari M, Inglebert Y, Ankri N, Russier M, Incontro S, Debanne D.
Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons Proceedings of the National Academy of Sciences USA, 119 : e2205264119 - 2021 - Fékété A, Ankri N, Brette R, Debanne D.
Neural excitability increases with axonal resistance between soma and axon initial segment Proceedings of the National Academy of Sciences USA, 118 : e2102217118 - 2021 - Inglebert Y, Debanne D.
Calcium and spike timing-dependent plasticity Frontiers in Cellular Neuroscience, 15 : 727336 - 2021 - Zhang W, Ciorraga M, Mendez P, Retana D, Boumedine N, Achon B, Russier M, Debanne D, Garrido JJ.
Formin activity and mDia1 contribute to maintain axon initial segment composition and structure Molecular Neurobiology : doi: 10.1007/s12035-021-02531-6 - 2021 - Incontro S, Sammari M, Azzaz F, Inglebert Y, Ankri N, Russier M, Fantini J, Debanne D.
Endocannabinoids tune intrinsic excitability in O-LM interneurons by direct modulation of post-synaptic Kv7 channels Journal of Neuroscience, 41 : 9521-9538 - 2021 - Duménieu M, Marqueze B, Russier M, Debanne D.
Mechanisms of plasticity in subcortical visual areas Cells, 10 : 3162 - 2021 - Zbili M, Rama S, Benitez MJ, Fronzaroli-Molinieres L, Bialowas A, Boumedine N, Garrido JJ, Debanne D.
Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit Proceedings of the National Academy of Sciences USA, 118 : e2110601118 - 2020 - Zbili M, Rama S, Yger P, Inglebert Y, Boumedine N, Fronzaroli-Molinieres L, Brette R, Russier M, Debanne D
Axonal Na+ channels detect and transmit levels of input synchrony in local brain circuits Science Advances, 6 : eaay4313 - 2020 - Zbili M, Debanne D.
Myelination Increases the Spatial Extent of Analog-Digital Modulation of Synaptic Transmission: A Modeling Study. Frontiers in Cellular Neuroscience, 14 : 40 - 2020 - Kamiya H, Debanne D.
Editorial: Axon neurobiology: fine scale dynamics of microstructure and function Frontiers in Cellular Neuroscience, 14 : 594361 - 2020 - Inglebert Y, Aljadeff J, Brunel N, Debanne D.
Synaptic plasticity rules with physiological calcium levels Proceedings of the National Academy of Sciences USA, 117 : 33639-33648 - 2019 - Debanne D, Inglebert Y, Russier M.
Plasticity of intrinsic neuronal excitability Current Opinion in Neurobiology, 54 : 73-82 - 2019 - Rama S, Boumedine N, Sangiardi M, Youssouf F, Maulet Y, Lévêque C, Belghazi M, Seagar M, Debanne DEl Far O.
Chromophore-assisted light inactivation of the V-ATPase V0c subunit inhibits neurotransmitter release downstream of synaptic vesicle acidification Molecular Neurobiology, 56 : 3591-3602 - 2019 - Zbili M, Debanne D.
Past and future of analog-digital modulation of synaptic transmission Frontiers in Cellular Neuroscience, 13 : 160 - 2019 - Debanne D, Russier M.
The contribution of ion channels in input-output plasticity Neurobiology of Learning and Memory, 166 : 107095 - 2019 - Steidl E, Gleyzes M, Maddalena F, Debanne D, Buisson B.
Neuroservice proconvulsive (NS-PC) set: A new platform of electrophysiology-based assays to determine the proconvulsive potential of lead compounds Journal of Pharmacological and Toxicological Methods, in press - 2018 - Rama S, Zbili M, Debanne D.
Signal propagation along the axon Current Opinion in Neurobiology, 51 : 37-44 - 2018 - Fékété A, Debanne D.
Somatic modulation of ectopic action potential initiation in distal axons Journal of Physiology (London), 596 : 5067-5068 - 2018 - Debanne D, El Far O.
Pre- and post-synaptic effects of LGI1 autoantibodies in a murine model of limbic encephalitis Brain, 141 : 3092-3095 - 2018 - Debanne D, Garrido J.
Axon initial segment Encyclopedia of Life Sciences : a00004 - 2017 - Rama S, Zbili M, Fékété A, Tapia M, Benitez MJ, Boumedine N, Garrido JJ, Debanne D.
The role of axonal Kv1 channels in CA3 pyramidal cell excitability Scientific Reports, 7 : 315 - 2017 - Debanne D, Russier M.
How do electrical synapses regulate their strength? Journal of Physiology (London), 595 : 4121-4122 - 2017 - Seagar M, Russier M, Caillard O, Maulet Y, Fronzaroli-Molinieres L, De San Feliciano M, Boumedine N, Rodriguez L, Zbili MUsseglio F, Formisano-Treziny C, Youssouf F, Sangiardi M, Boillot M, Baulac S, Benitez MJ, Garrido JJ, Debanne DEl Far O.
LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels Proceedings of the National Academy of Sciences USA, 114 : 7719-7724 - 2017 - Gasselin C, Inglebert Y, Ankri N, Debanne D.
Plasticity of intrinsic excitability during LTD is mediated by bidirectional changes in h-channel activity Scientific Reports, 7 : 14418 - 2016 - Zbili M, Rama S, Debanne D.
Dynamic control of neurotransmitter release by presynaptic potential Frontiers in Cellular Neuroscience, 10 : 278 - 2015 - Del Puerto, Fronzaroli-Molinieres L, Perez-Alvarez MJ, Giraud P, Carlier E, Wandosell, F, Debanne D, Garrido, JJ.
ATP-P2X7 Receptor Modulates Axon Initial Segment Composition and Function in Physiological Conditions and Brain Injury Cerebral Cortex, 25 : 2282-2294 - 2015 - Bialowas A, Rama S, Zbili M, Marra V, Fronzaroli-Molinieres L, Ankri N, Carlier E, Debanne D.
Analog modulation of spike-evoked transmission in CA3 circuits is determined by Kv1.1 channels in a time-dependent manner European Jounral of Neuroscience, 41 : 293-304 - 2015 - Rama S, Zbili M, Debanne D.
Modulation of spike-evoked synaptic transmission: The role of presynaptic calcium and potassium channels Biochimica et Biophysica Acta (BBA)- Molecular Cell Research, 1853 : 1933-1939 - 2015 - Gasselin C, Inglebert Y, Debanne D.
Homeostatic regulation of h-conductance controls intrinsic excitability and stabilizes the threshold for synaptic modification in CA1 neurons Journal of Physiology (London), 593 : 4855-4869 - 2015 - Rama S, Zbili M, Bialowas A, Fronzaroli-Molinieres L, Ankri N, Carlier E, Marra V, Debanne D.
Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels Nature Communications, 6 : 10163 - 2015 - Hammond C, Debanne D, Goaillard JM.
Somato-dendritic processing of postsynaptic potentials II. Role of sub-threshold depolarizing voltage-gated currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D.
Somato-dendritic processing of postsynaptic potential III. Role of high-voltage-activated depolarizing currents Cellular and molecular neurophysiology - 2015 - Hammond, Goaillard JM, Debanne D, Gaiarsa JL.
Synaptic plasticity Cellular and molecular neurophysiology - 2014 - Debanne D, Campanac E.
Memory (mechanisms other than LTP) Encyclopedia of Life Sciences - 2014 - Mlayah-Bellalouna S, Dufour M, Mabrouk S, Mejdoub, H, Carlier E, Othman H, Belghazi M, Tarbe M, Goaillard JM, Gigmes D, Seagar M, El Ayeb M, Debanne D, Srairi-Abid N.
AaTX1, from Androctonus australis scorpion venom: Purification, synthesis and characterization in dopaminergic neurons Toxicon, 92 : 14-23 - 2013 - Debanne D, Bialowas A, Rama S.
What are the mechanisms for analog and digital signaling in the brain? Nature Reviews Neuroscience, 14 : 63-69 - 2013 - Tapia M, Del Puerto A, Puime A, Sánchez-Ponce D, Fronzaroli-Molinieres L, Pallas-Bazarra N, Carlier E, Giraud P, Debanne D, Wandossell F, Garrido JJ.
GSK3 and β-catenin determine functional expression of sodium channels at the axon initial segment Cellular and Molecular Life Sciences, 70 : 105-120 - 2013 - Campanac E, Gasselin C, Baude A, Rama S, Ankri N, Debanne D.
Enhanced intrinsic excitability in basket cells maintains excitatory-inhibitory balance in hippocampal circuits Neuron, 77 : 712-722 - 2011 - Debanne D, Rama S.
Astrocytes shape axonal signaling. Science Signaling, 4 : pe11 - 2011 - Gastrein P, Campanac E, Gasselin C, Cudmore RH, Bialowas A, Carlier E, Fronzaroli-Molinieres L, Debanne D.
The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro. Journal of Physiology (London), 589 : 3753-3773 - 2011 - Debanne D.
The nodal origin of intrinsic bursting Neuron, 71 : 569-570 - 2011 - Debanne D, Campanac E, Bialowas A, Carlier E, Alcaraz G.
Axon physiology Physiological Reviews, 91 : 555-602 - 2011 - Boudkkazi S, Fronzaroli-Molinieres L, Debanne D.
Presynaptic action potential waveform determines cortical synaptic latency Journal of Physiology (London), 589 : 1117-1131 - 2011 - Gaudioso C, Carlier E, Youssouf F, Clare JJ, Debanne D, Alcaraz G.
Calmodulin and calcium differentially regulate the neuronal Nav1.1 voltage-dependent sodium channel. Biochem Biophys Res Commun, 411 : 329-334 - 2010 - Di Giovanni J, Boudkkazi S, Mochida S, Bialowas A, Samari N, Lévêque C, Youssouf F, Brechet A, Iborra CMaulet Y, Moutot N, Debanne D, Seagar M, El Far O.
V-ATPase membrane sector associates with synaptobrevin to modulate neurotransmitter release. Neuron, 67 : 268-279 - 2010 - Cudmore RH, Fronzaroli-Molinieres L, Giraud P, Debanne D.
Spike-time precision and network synchrony are controlled by the homeostatic regulation of the D-type potassium current. Journal of Neuroscience, 30 : 12885-12895 - 2010 - Caillard O, Debanne D.
Cell-specific contribution to gamma oscillations. Journal of Physiology (London), 588 : 751 - 2010 - Debanne D, Poo MM.
Spike-timing dependent plasticity beyond synapse - pre- and post-synaptic plasticity of intrinsic neuronal excitability. Frontiers in Synaptic Neuroscience, 2 : 21 - 2010 - Froemke RC, Debanne D, Bi GQ.
Temporal modulation of spike-timing-dependent plasticity. Frontiers in Synaptic Neuroscience, 2 : 19 - 2009 - Debanne D, Campanac E.
Memory: mechanisms other than LTP Encyclopedia of Life Sciences - 2009 - Debanne D.
Plasticity of neuronal excitability in vivo Journal of Physiology (London), 587 : 3057-3058 - 2008 - Debanne D, Boudkkazi S, Campanac E, Cudmore RH, Giraud P, Fronzaroli-Molinieres L, Carlier E, Caillard O.
Paired-recordings from synaptically coupled cortical and hippocampal neurons in acute and cultured brain slices. Nature Protocols, 3 : 1559-1568 - 2008 - Campanac E, Daoudal G, Ankri N, Debanne D.
Downregulation of dendritic I(h) in CA1 pyramidal neurons after LTP. Journal of Neuroscience, 28 : 8635-8643 - 2008 - Campanac E, Debanne D.
Spike timing-dependent plasticity: a learning rule for dendritic integration in rat CA1 pyramidal neurons. Journal of Physiology (London), 586 : 779-793 - 2007 - Cudmore RH, Goaillard JM, Debanne D.
Inhibition facilitates depression. Journal of Physiology (London), 585 : 323 - 2007 - Boudkkazi S, Carlier E, Ankri N, Caillard O, Giraud P, Fronzaroli-Molinieres L, Debanne D.
Release-dependent variations in synaptic latency: a putative code for short- and long-term synaptic dynamics. Neuron, 56 : 1048-1060 - 2007 - Campanac E, Debanne D.
Plasticity of neuronal excitability: Hebbian rules beyond the synapse. Archives Italiennes de Biologie, 145 : 277-287 - 2006 - Carlier E, Sourdet V, Boudkkazi S, Déglise P, Ankri N, Fronzaroli-Molinieres L, Debanne D.
Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons. Journal of Physiology (London), 577 : 141-154 - 2006 - Debanne D, Gastrein P, Campanac E.
Queer channels in hippocampal basket cells: h-current without sag. Journal of Physiology (London), 574 : 2 - 2006 - Bouzioukh F, Daoudal G, Falk J, Debanne D, Rougon G, Castellani V.
Semaphorin3A regulates synaptic function of differentiated hippocampal neurons. European Journal of Neuroscience, 23 : 2247-2254 - 2006 - Debanne D, Thomspon SM, Gähwiler BH.
A brief period of epileptiform activity strengthens excitatory synapses in the rat hippocampus in vitro. Epilepsia, 47 : 247-256 - 2004 - Debanne D.
Information processing in the axon. Nature Reviews Neuroscience, 5 : 304-316 - 2003 - Daoudal G, Debanne D.
Long-term plasticity of intrinsic excitability: learning rules and mechanisms. Learning & Memory, 10 : 456-465 - 2003 - Sourdet V, Russier M, Daoudal G, Ankri N, Debanne D.
Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5. Journal of Neuroscience, 23 : 10238-10248 - 2003 - Debanne D, Daoudal G, Sourdet V, Russier M.
Brain plasticity and ion channels. Journal of Physiology (Paris), 97 : 403-414 - 2003 - Garrido JJ, Giraud P, Carlier E, Fernandes F, Moussif A, Fache MP, Debanne D, Dargent B.
A targeting motif involved in sodium channel clustering at the axonal initial segment. Science, 300 : 2091-2094 - 2003 - Russier M, Carlier E, Ankri N, Fronzaroli-Molinieres L, Debanne D.
A-, T-, and H-type currents shape intrinsic firing of developing rat abducens motoneurons. Journal of Physiology (London), 549 : 21-36 - 2003 - Russier M, Debanne D.
Axonal propagation: does the spike stop here? Journal of Physiology (London), 548 : 663 - 2002 - Daoudal G, Hanada Y, Debanne D.
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences USA, 99 : 14512-14517 - 2002 - Russier M, Kopysova I, Ankri N, Ferrand N, Debanne D.
GABA and glycine co-release optimizes functional inhibition in rat brainstem motoneurons in vitro. Journal of Physiology (London), 541 : 123-137 - 1999 - Debanne D, Gähwiler BH, Thompson SM.
Heterogeneity of synaptic plasticity at unitary CA3-CA1 and CA3-CA3 connections in rat hippocampal slice cultures. Journal of Neuroscience, 19 : 10664-10671 - 1999 - Sourdet V, Debanne D.
The role of dendritic filtering in associative long-term synaptic plasticity. Learning & Memory, 6 : 422-447 - 1998 - Kopysova IL, Debanne D.
Critical role of axonal A-type K+ channels and axonal geometry in the gating of action potential propagation along CA3 pyramidal cell axons: a simulation study. Journal of Neuroscience, 18 : 7436-7451 - 1998 - Debanne D, Shulz DE, Frégnac Y.
Activity-dependent regulation of 'on' and 'off' responses in cat visual cortical receptive fields. Journal of Physiology (London), 508 : 523-548 - 1998 - Debanne D, Gähwiler BH, Thompson SM.
Long-term synaptic plasticity between pairs of individual CA3 pyramidal cells in rat hippocampal slice cultures. Journal of Physiology (London), 507 : 237-247 - 1997 - Debanne D, Guérineau NC, Gähwiler BH, Thompson SM.
Action-potential propagation gated by an axonal I(A)-like K+ conductance in hippocampus. Nature, 389 : 286-289 - 1997 - McKinney RA, Debanne D, Gähwiler BH, Thompson SM.
Lesion-induced axonal sprouting and hyperexcitability in the hippocampus in vitro: implications for the genesis of posttraumatic epilepsy. Nature Medicine, 3 : 990-996 - 1997 - Debanne D, Gähwiler BH, Thompson SM.
Bidirectional associative plasticity of unitary CA3-CA1 EPSPs in the rat hippocampus in vitro. Journal of Neurophysiology, 77 : 2851-2855 - 1996 - Debanne D, Gähwiler BH, Thompson SM.
Cooperative interactions in the induction of long-term potentiation and depression of synaptic excitation between hippocampal CA3-CA1 cell pairs in vitro. Proceedings of the National Academy of Sciences USA, 93 : 11225-11230 - 1996 - Debanne D, Guérineau NC, Gähwiler BH, Thompson SM.
Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release. Journal of Physiology (London), 491 : 163-176 - 1995 - Debanne D, Guérineau NC, Gähwiler BH, Thompson SM.
Physiology and pharmacology of unitary synaptic connections between pairs of cells in areas CA3 and CA1 of rat hippocampal slice cultures. Journal of Neurophysiology, 73 : 1282-1294 - 1994 - Debanne D, Gähwiler BH, Thompson SM.
Asynchronous pre- and postsynaptic activity induces associative long-term depression in area CA1 of the rat hippocampus in vitro. Proceedings of National Academy of Sciences USA, 91 : 1148-1152
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